Biology of metabolic syndrome in a vascular patient

Metabolic syndrome is highly prevalent in vascular patients and has a significant impact on the outcomes of vascular interventions. It comprises of a set of metabolically driven risk factors, including truncal obesity, dyslipidemia, elevated blood pressure and elevated fasting blood glucose. Increas...

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Bibliographic Details
Published in:Vascular 2012-06, Vol.20 (3), p.156-165
Main Authors: Vykoukal, Daynene, Davies, Mark G
Format: Article
Language:English
Subjects:
Dyslipidemias - complications
Dyslipidemias - physiopathology
Endothelium, Vascular - physiopathology
Humans
Hyperglycemia - complications
Hyperglycemia - physiopathology
Hypertension - complications
Hypertension - physiopathology
Insulin Resistance
Metabolic Syndrome - complications
Metabolic Syndrome - physiopathology
Obesity - complications
Obesity - physiopathology
Vascular Diseases - complications
Vascular Diseases - surgery
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Summary:Metabolic syndrome is highly prevalent in vascular patients and has a significant impact on the outcomes of vascular interventions. It comprises of a set of metabolically driven risk factors, including truncal obesity, dyslipidemia, elevated blood pressure and elevated fasting blood glucose. Increased insulin resistance within the context of obesity and hypertension contributes to atherogenic dyslipidemia, hyperglycemia, and prothrombotic and proinflammatory states which lead to the adverse impact of metabolic syndrome on the response to injury and on atherosclerotic disease progression. This review focuses on the complex biology of metabolic syndrome and its relevance to management of vascular patients, including outcomes and implications for the coronary, cerebrovascular and lower-extremity vascular beds.
ISSN:1708-5381
1708-539X
DOI:10.1258/vasc.2011.201201