Bioactive 3,4-seco-Triterpenoids from the Fruits of Acanthopanax sessiliflorus

Eight new 3,4-seco-lupane triterpenes and glycosides, acanthosessiligenins I and II (1, 3) and acanthosessiliosides A–F (2, 4–8), as well as six known 3,4-seco-lupane triterpenes (9–14) were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures of 1–8 were...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2012-06, Vol.75 (6), p.1138-1144
Main Authors: Lee, Dae-Young, Seo, Kyeong-Hwa, Lee, Dong-Sung, Kim, Youn-Chul, Chung, In-Sik, Kim, Gye-Won, Cheoi, Dae-Sung, Baek, Nam-In
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Drug Screening Assays, Antitumor
Eleutherococcus - chemistry
Fruit - chemistry
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Humans
Korea
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Mice
Molecular Structure
Nitric Oxide - biosynthesis
Nuclear Magnetic Resonance, Biomolecular
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Summary:Eight new 3,4-seco-lupane triterpenes and glycosides, acanthosessiligenins I and II (1, 3) and acanthosessiliosides A–F (2, 4–8), as well as six known 3,4-seco-lupane triterpenes (9–14) were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures of 1–8 were determined by spectroscopic data interpretation. All isolated compounds were tested for their cytotoxicity against six human cancer cell lines and their ability to inhibit LPS-induced nitric oxide production in RAW 264.7 macrophages.
ISSN:0163-3864
1520-6025
DOI:10.1021/np3002173