Liver Injury Due to Chemotherapy-induced Sinusoidal Obstruction Syndrome Is Associated with Sinusoidal Capillarization

Background Indocyanine green (ICG) retention is a validated test of hepatic function in patients with chronic liver disease. The underlying mechanism for the impairment of ICG retention in patients undergoing chemotherapy for colorectal liver metastases (CLM) remains unclear. We sought to elucidate...

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Bibliographic Details
Published in:Annals of surgical oncology 2012-07, Vol.19 (7), p.2230-2237
Main Authors: Narita, Masato, Oussoultzoglou, Elie, Chenard, Marie-Pierre, Fuchshuber, Pascal, Rather, Muddasar, Rosso, Edoardo, Addeo, Pietro, Jaeck, Daniel, Bachellier, Philippe
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - adverse effects
Antineoplastic Agents, Phytogenic - therapeutic use
Camptothecin - analogs & derivatives
Camptothecin - therapeutic use
Chemical and Drug Induced Liver Injury - etiology
Colorectal Neoplasms - complications
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - pathology
Combined Modality Therapy
Female
Follow-Up Studies
Hepatectomy
Hepatic Veno-Occlusive Disease - chemically induced
Hepatobiliary Tumors
Humans
Indocyanine Green
Liver Neoplasms - complications
Liver Neoplasms - drug therapy
Liver Neoplasms - secondary
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Neovascularization, Pathologic - etiology
Oncology
Organoplatinum Compounds - adverse effects
Prognosis
Risk Factors
Surgery
Surgical Oncology
Survival Rate
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Summary:Background Indocyanine green (ICG) retention is a validated test of hepatic function in patients with chronic liver disease. The underlying mechanism for the impairment of ICG retention in patients undergoing chemotherapy for colorectal liver metastases (CLM) remains unclear. We sought to elucidate the mechanism for impairment of ICG retention in patients with CLM. Methods Clinicopathologic data of 98 patients with CLM undergoing hepatectomy were analyzed. The archived nontumoral liver parenchyma bearing no CLM were immunostained with CD34 antibody to determine the sinusoidal capillarization. Results Of 98 patients, 80 received preoperative chemotherapy. Sinusoidal obstruction syndrome (SOS) occurred in 39 patients (39.8%). The development of SOS in patients receiving oxaliplatin-based chemotherapy was significantly higher compared to those receiving non-oxaliplatin-based chemotherapy ( P  = 0.003). SOS was independently associated with abnormal ICG retention rate at 15 minutes (ICG-R15) (odds ratio 3.45, 95% confidence interval 1.31–9.04, P  = 0.012) and CD 34 overexpression (odds ratio 18.76, 95% confidence interval 4.58–76.81, P  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-011-2112-6