Depressive symptoms in HIV-infected patients treated with highly active antiretroviral therapy

The prevalence of depressive disorders in HIV-infected patients ranges from 12% to 66% and is undiagnosed in 50% to 60% of these patients. Depression in HIV-infected individuals may be associated with poor antiretroviral treatment (ART) outcomes, since it may direct influence compliance. To assess t...

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Bibliographic Details
Published in:Revista brasileira de psiquiatria 2012-06, Vol.34 (2), p.162-167
Main Authors: Silveira, Marysabel Pinto Telis, Guttier, Marília Cruz, Pinheiro, Cezar Arthur Tavares, Pereira, Tatiana Vanessa Silveira, Cruzeiro, Ana Laura Sica, Moreira, Leila Beltrami
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antiretroviral Therapy, Highly Active - psychology
Brazil - epidemiology
Cross-Sectional Studies
Depression - diagnosis
Depression - epidemiology
Female
HIV Infections - drug therapy
HIV Infections - psychology
Humans
Male
Middle Aged
Prevalence
Risk Factors
Socioeconomic Factors
Young Adult
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Summary:The prevalence of depressive disorders in HIV-infected patients ranges from 12% to 66% and is undiagnosed in 50% to 60% of these patients. Depression in HIV-infected individuals may be associated with poor antiretroviral treatment (ART) outcomes, since it may direct influence compliance. To assess the presence of symptoms and risk factors for depression in patients on ART. Cross-sectional study. Certified interviewers administered questionnaires and the Beck Depression Inventory (BDI), and participants' self-reported compliance to ART. Clinical and laboratory variables were obtained from clinical records. Patients with BDI > 12 were defined as depressed. RESULTS Out of the 250 patients invited to participate, 246 (98%) consented. Mean age was 41 ± 9.9 years; most were male (63%). Income ranged from 0-14 Brazilian minimum wages. AIDS (CDC stage C) had been diagnosed in 97%, and 81% were in stable immune status. One hundred ninety-one (78%) reported compliance, and 161 (68%) had undetectable viral loads. The prevalence of depressive symptoms was 32% (95% CI 26-40). In multivariate analysis, depressive symptoms were significantly associated with income (prevalence ratio [PR] = 0.85; 95% CI 0.74-0.97; p = 0.02). Depressive symptoms are frequent in patients on ART, and are associated with low income.
ISSN:1516-4446
1809-452X
DOI:10.1016/S1516-4446(12)70034-X