Rhythmic 24-hour variations of frequently used clinical biochemical parameters in healthy young males - The Bispebjerg study of diurnal variations

Purpose. To evaluate the influence of time of day on the circulating concentrations of 14 frequently used clinical biochemical parameters in the Bispebjerg study of diurnal variations. Materials and methods. Venous blood samples were obtained under controlled environmental, activities and food condi...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2012-07, Vol.72 (4), p.287-295
Main Authors: Sennels, Henriette P., Jørgensen, Henrik L., Goetze, Jens P., Fahrenkrug, Jan
Format: Article
Language:English
Subjects:
24-hour rhythm
Adult
Aspartate Aminotransferases - blood
Bilirubin - blood
Biological and medical sciences
Biological clocks
Biomarkers - blood
biorhythms
Blood Proteins - metabolism
Blood Urea Nitrogen
chronobiology
Circadian Rhythm
circadian rhythms
Creatine Kinase - blood
diurnal variations
Glomerular Filtration Rate
Humans
Investigative techniques, diagnostic techniques (general aspects)
L-Lactate Dehydrogenase - blood
Male
Medical sciences
Melatonin - blood
Potassium - blood
Sodium - blood
Uric Acid - blood
Young Adult
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Summary:Purpose. To evaluate the influence of time of day on the circulating concentrations of 14 frequently used clinical biochemical parameters in the Bispebjerg study of diurnal variations. Materials and methods. Venous blood samples were obtained under controlled environmental, activities and food conditions from 24 healthy young men every third hour through 24 hours, nine time points in total. At each time point, the parameters' concentrations were measured. The data were analyzed by rhythmometric statistical methods and in addition the biological variations were calculated. Results. Significant oscillation of melatonin with an amplitude (amp) of 19.84 pg/ml and a peak at 03:34 h confirmed the normal 24-hour rhythms of the participants. Potassium (p
ISSN:0036-5513
1502-7686
DOI:10.3109/00365513.2012.662281