Evaluation of visual recognition memory for the early diagnosis of Alzheimer's disease in patients over 75 years

Current diagnostic criteria of Alzheimer Disease (AD) are mainly based on clinical definition. In France, the Delayed Matching Sample (DMS48) test, a recently introduced test that explores visual object recognition, is recommended for the early diagnosis of AD. However, little is known on the DMS48...

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Published in:Revue neurologique 2012-06, Vol.168 (6-7), p.483-487
Main Authors: Poissonnet, A., Henry-Feugeas, M.-C., Drunat, O., Wolmark, Y., Delpierre, S., Koskas, P.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer disease (AD)
Alzheimer Disease - diagnosis
Alzheimer Disease - psychology
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - psychology
Delayed matching sample
DMS 48
Early Diagnosis
Educational Status
Elderly people
Female
Free and cued selective reminding test
Grober et Buschke RL/RI 16 items
Humans
Maladie d’Alzheimer
Male
Memory - physiology
Mental Recall - physiology
Mild cognitive impairment (MCI)
Neuropsychological Tests
Patients âgés
Recognition (Psychology) - physiology
Reproducibility of Results
Trouble cognitif léger
Visual Perception - physiology
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Koskas, P.
description Current diagnostic criteria of Alzheimer Disease (AD) are mainly based on clinical definition. In France, the Delayed Matching Sample (DMS48) test, a recently introduced test that explores visual object recognition, is recommended for the early diagnosis of AD. However, little is known on the DMS48 performances of older subjects over 75 years. Therefore, our aim was to assess its specific clinical value for early detection of AD in older patients. We studied 93 consecutive patients over 75 years from an expert memory clinic in a geriatric hospital. This population included 31 patients with single domain amnestic Mild Cognitive Impairment (aMCI), 31 AD patients and 31 controls subjects. The aMCI and AD performances on the DMS48 were significantly lower than those of the control subjects (set 1 and set 2, P
doi_str_mv 10.1016/j.neurol.2011.11.004
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In France, the Delayed Matching Sample (DMS48) test, a recently introduced test that explores visual object recognition, is recommended for the early diagnosis of AD. However, little is known on the DMS48 performances of older subjects over 75 years. Therefore, our aim was to assess its specific clinical value for early detection of AD in older patients. We studied 93 consecutive patients over 75 years from an expert memory clinic in a geriatric hospital. This population included 31 patients with single domain amnestic Mild Cognitive Impairment (aMCI), 31 AD patients and 31 controls subjects. The aMCI and AD performances on the DMS48 were significantly lower than those of the control subjects (set 1 and set 2, P&lt;10−7). The DMS48 performances in the healthy group appeared closely related to the previously published normative data. However, the DMS48 performances appeared unexpectedly high in these older patients, especially in the AD subgroup (set 1, 82.2±12.1 and set 2, 75.2±16.2). Moreover, there was an unexpected frequent discordance between the results on the DMS48 and the Free and Cued Selective Reminding tests (FCSR). The DMS test appears useful for highlighting the heterogeneity of the syndromes of aMCI and AD in old-old people aged 75+: our results also underline the need for further characterization of cognitive impairment in this fastest growing subgroup of patients. Actuellement, les critères diagnostiques de la maladie d’Alzheimer (MA) sont principalement basés sur une définition clinique. En France, le delayed matching sample (DMS48) est désormais recommandé. Il s’agit d’un test récemment présenté qui explore la reconnaissance visuelle en vue d’un diagnostic précoce de la MA. Cependant, on connaît encore peu les performances à ce test des patients âgés de plus de 75ans. Notre but est donc d’évaluer la valeur clinique de ce test pour un diagnostic précoce des patients de plus de 75ans. Nous avons étudié 93 patients consécutifs de plus de 75ans dans le cadre d’une consultation mémoire au sein d’un hôpital gériatrique. Ont été inclus 31 patients présentant un déclin cognitif léger touchant uniquement la mémoire (aMCI), 31 patients présentant une MA et 31 sujets témoins. Les résultats au DMS48 des patients aMCI et des patients atteints de MA sont significativement plus faibles que ceux des sujets témoins (set 1 et set 2, p&lt;10−7). Les performances au DMS48 du groupe témoin sont apparues étroitement liées aux données normatives précédemment publiées. Cependant, les performances des patients âgés sont étonnamment plus élevés que les performances attendues des patients jeunes et particulièrement dans le groupe des patients atteints de MA (set 1, 82,2±12,1 et set 2 75,2±16,2). De plus, il y a également une discordance inattendue entre les résultats au DMS48 et au Grober et Buschke RL/RI 16 items. 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In France, the Delayed Matching Sample (DMS48) test, a recently introduced test that explores visual object recognition, is recommended for the early diagnosis of AD. However, little is known on the DMS48 performances of older subjects over 75 years. Therefore, our aim was to assess its specific clinical value for early detection of AD in older patients. We studied 93 consecutive patients over 75 years from an expert memory clinic in a geriatric hospital. This population included 31 patients with single domain amnestic Mild Cognitive Impairment (aMCI), 31 AD patients and 31 controls subjects. The aMCI and AD performances on the DMS48 were significantly lower than those of the control subjects (set 1 and set 2, P&lt;10−7). The DMS48 performances in the healthy group appeared closely related to the previously published normative data. However, the DMS48 performances appeared unexpectedly high in these older patients, especially in the AD subgroup (set 1, 82.2±12.1 and set 2, 75.2±16.2). 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Le DMS48 apparaît utile pour mettre en évidence l’hétérogénéité des syndromes amnésiques des patients MCI et des patients atteints de MA, notamment chez les patients âgées de plus de 75ans : nos résultats soulignent le besoin de la nouvelle caractérisation des troubles cognitifs qui sont de nos jours en croissance au vu de la population vieillissante.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer disease (AD)</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - psychology</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Delayed matching sample</subject><subject>DMS 48</subject><subject>Early Diagnosis</subject><subject>Educational Status</subject><subject>Elderly people</subject><subject>Female</subject><subject>Free and cued selective reminding test</subject><subject>Grober et Buschke RL/RI 16 items</subject><subject>Humans</subject><subject>Maladie d’Alzheimer</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Mental Recall - physiology</subject><subject>Mild cognitive impairment (MCI)</subject><subject>Neuropsychological Tests</subject><subject>Patients âgés</subject><subject>Recognition (Psychology) - physiology</subject><subject>Reproducibility of Results</subject><subject>Trouble cognitif léger</subject><subject>Visual Perception - physiology</subject><issn>0035-3787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRb0A0VL4A4S8g02L47zcDVJVlYdUiQ2srUkyaV0lcbCTSOXrmdLCEmkkW-N7Z3wPYzeBmAUiSB52swZ7Z6uZFEEwoxIiOmNjIcJ4GqYqHbFL73dCyCAV4QUbSRmJOIrVmLWrAaoeOmMbbks-GN9DxR3mdtOYn26NtXV7XlrHuy1yBFfteWFg01hv_MG0qL62aGp0d54ePIJHbhre0lRsOpIM6Hga8z15_RU7L6HyeH06J-zjafW-fJmu355fl4v1NA8T2U2TrKAMIFBBAKpESilByXkWAwqIJYR0L1UCiYiisFBxJgGUwnmeqHkeYzhh98e5rbOfPfpO18bnWFXQoO29DoSUYZrSMpJGR2nurPcOS906U4Pbk0gf-OqdPvLVB76aiv5GttvThj6rsfgz_cIlweNRgJRzMOi0z4lIjoUhwJ0urPl_wzcgN5FO</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Poissonnet, A.</creator><creator>Henry-Feugeas, M.-C.</creator><creator>Drunat, O.</creator><creator>Wolmark, Y.</creator><creator>Delpierre, S.</creator><creator>Koskas, P.</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Evaluation of visual recognition memory for the early diagnosis of Alzheimer's disease in patients over 75 years</title><author>Poissonnet, A. ; 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In France, the Delayed Matching Sample (DMS48) test, a recently introduced test that explores visual object recognition, is recommended for the early diagnosis of AD. However, little is known on the DMS48 performances of older subjects over 75 years. Therefore, our aim was to assess its specific clinical value for early detection of AD in older patients. We studied 93 consecutive patients over 75 years from an expert memory clinic in a geriatric hospital. This population included 31 patients with single domain amnestic Mild Cognitive Impairment (aMCI), 31 AD patients and 31 controls subjects. The aMCI and AD performances on the DMS48 were significantly lower than those of the control subjects (set 1 and set 2, P&lt;10−7). The DMS48 performances in the healthy group appeared closely related to the previously published normative data. However, the DMS48 performances appeared unexpectedly high in these older patients, especially in the AD subgroup (set 1, 82.2±12.1 and set 2, 75.2±16.2). Moreover, there was an unexpected frequent discordance between the results on the DMS48 and the Free and Cued Selective Reminding tests (FCSR). The DMS test appears useful for highlighting the heterogeneity of the syndromes of aMCI and AD in old-old people aged 75+: our results also underline the need for further characterization of cognitive impairment in this fastest growing subgroup of patients. Actuellement, les critères diagnostiques de la maladie d’Alzheimer (MA) sont principalement basés sur une définition clinique. En France, le delayed matching sample (DMS48) est désormais recommandé. Il s’agit d’un test récemment présenté qui explore la reconnaissance visuelle en vue d’un diagnostic précoce de la MA. Cependant, on connaît encore peu les performances à ce test des patients âgés de plus de 75ans. Notre but est donc d’évaluer la valeur clinique de ce test pour un diagnostic précoce des patients de plus de 75ans. Nous avons étudié 93 patients consécutifs de plus de 75ans dans le cadre d’une consultation mémoire au sein d’un hôpital gériatrique. Ont été inclus 31 patients présentant un déclin cognitif léger touchant uniquement la mémoire (aMCI), 31 patients présentant une MA et 31 sujets témoins. Les résultats au DMS48 des patients aMCI et des patients atteints de MA sont significativement plus faibles que ceux des sujets témoins (set 1 et set 2, p&lt;10−7). Les performances au DMS48 du groupe témoin sont apparues étroitement liées aux données normatives précédemment publiées. Cependant, les performances des patients âgés sont étonnamment plus élevés que les performances attendues des patients jeunes et particulièrement dans le groupe des patients atteints de MA (set 1, 82,2±12,1 et set 2 75,2±16,2). De plus, il y a également une discordance inattendue entre les résultats au DMS48 et au Grober et Buschke RL/RI 16 items. Le DMS48 apparaît utile pour mettre en évidence l’hétérogénéité des syndromes amnésiques des patients MCI et des patients atteints de MA, notamment chez les patients âgées de plus de 75ans : nos résultats soulignent le besoin de la nouvelle caractérisation des troubles cognitifs qui sont de nos jours en croissance au vu de la population vieillissante.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>22405458</pmid><doi>10.1016/j.neurol.2011.11.004</doi><tpages>5</tpages></addata></record>
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subjects Aged
Aged, 80 and over
Alzheimer disease (AD)
Alzheimer Disease - diagnosis
Alzheimer Disease - psychology
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - psychology
Delayed matching sample
DMS 48
Early Diagnosis
Educational Status
Elderly people
Female
Free and cued selective reminding test
Grober et Buschke RL/RI 16 items
Humans
Maladie d’Alzheimer
Male
Memory - physiology
Mental Recall - physiology
Mild cognitive impairment (MCI)
Neuropsychological Tests
Patients âgés
Recognition (Psychology) - physiology
Reproducibility of Results
Trouble cognitif léger
Visual Perception - physiology
title Evaluation of visual recognition memory for the early diagnosis of Alzheimer's disease in patients over 75 years
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