Choroidal observations in Vogt–Koyanagi–Harada disease using high-penetration optical coherence tomography

Background The aim of this work was to investigate the choroidal morphologic changes of Vogt–Koyanagi–Harada (VKH) disease in vivo using high-penetration optical coherence tomography (HP-OCT) with a long-wavelength light source (1,060 nm). Methods Fourteen patients with VKH disease were included in...

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Published in:Graefe's archive for clinical and experimental ophthalmology 2012-07, Vol.250 (7), p.1089-1095
Main Authors: Nakai, Kei, Gomi, Fumi, Ikuno, Yasushi, Yasuno, Yoshiaki, Nouchi, Takeyoshi, Ohguro, Nobuyuki, Nishida, Kohji
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Choroid Diseases - diagnosis
Choroid Diseases - etiology
Coloring Agents
Female
Fluorescein Angiography
Glucocorticoids - therapeutic use
Humans
Indocyanine Green
Inflammatory Disorders
Male
Medicine
Medicine & Public Health
Methylprednisolone - therapeutic use
Middle Aged
Ophthalmology
Prednisolone - therapeutic use
Recurrence
Retrospective Studies
Tomography, Optical Coherence
Uveomeningoencephalitic Syndrome - complications
Uveomeningoencephalitic Syndrome - diagnosis
Uveomeningoencephalitic Syndrome - drug therapy
Visual Acuity
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Summary:Background The aim of this work was to investigate the choroidal morphologic changes of Vogt–Koyanagi–Harada (VKH) disease in vivo using high-penetration optical coherence tomography (HP-OCT) with a long-wavelength light source (1,060 nm). Methods Fourteen patients with VKH disease were included in this study: 12 eyes of six patients with treatment-naive acute VKH in the first 6–12 months after diagnosis and 16 eyes of eight patients in the convalescent phase with a sunset glow fundus appearance. A prototype HP-OCT instrument was used to observe the deep choroid and sclera. The choroidal thickness was measured for more than 6 months in eyes with acute disease. The choroidal thickness in patients with a sunset glow fundus appearance for 2–9 years after the onset was also examined. Results In 12 eyes with acute VKH disease, the baseline choroidal thickness was significantly ( p  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-011-1910-7