Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls

Meningioma, the most frequent tumor in the central nervous system, has few recognized risk factors. We explored the role of allergies in a population‐based case–control consortium study of meningioma in five geographic areas. We also studied serum levels of a marker of atopic allergy (IgE) in a subs...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cancer 2011-10, Vol.129 (8), p.1932-1939
Main Authors: Wiemels, Joseph L., Wrensch, Margaret, Sison, Jennette D., Zhou, Mi, Bondy, Melissa, Calvocoressi, Lisa, Black, Peter M., Yu, Herbert, Schildkraut, Joellen M., Claus, Elizabeth B.
Format: Article
Language:English
Subjects:
Allergies
Atopy
Bioindicators
Biological and medical sciences
biomarkers
brain tumor
Brain tumors
Cancer
Case-Control Studies
Central nervous system
epidemiology
Female
genetics
Glioma
Historical account
Humans
Hypersensitivity
Hypersensitivity - epidemiology
immune factors
Immunoglobulin E
Immunoglobulin E - blood
Male
Medical sciences
Meningeal Neoplasms - immunology
meningioma
Meningioma - immunology
Middle Aged
Neurology
neurosurgery
Risk factors
Serum levels
Tumors
Tumors of the nervous system. Phacomatoses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Meningioma, the most frequent tumor in the central nervous system, has few recognized risk factors. We explored the role of allergies in a population‐based case–control consortium study of meningioma in five geographic areas. We also studied serum levels of a marker of atopic allergy (IgE) in a subset of study participants, a first for a study on meningioma. Participants (N = 1,065) with surgically resected, pathologically confirmed meningioma and controls (N = 634) selected via random‐digit dialing were recruited and interviewed. Cases were less likely than controls to report history of physician‐diagnosed allergy [odds ratio (OR) = 0.64; 95% confidence interval (95% CI): 0.51–0.80]. Also, cases (N = 295) had lower total serum IgE than controls [N = 192; OR = 0.85, 95% CI: 0.75–0.98 for each unit of Ln(IgE)]. Similar to glioma and cancers at several other sites, meningioma appears to have an inverse relationship with history of allergies and a biomarker of atopic allergy. As some common opposing predisposition or developmental processes for allergy and meningioma may exist, further research into immune processes that can affect the incidence and natural history of meningioma is warranted.
ISSN:0020-7136
1097-0215
1097-0215
DOI:10.1002/ijc.25858