Synthesis, characterization, and antimicrobial activity of oxovanadium(IV)hydroxamate complexes

Vanadium(IV) complexes, [VO(acac)(HL 1,2 )] and [VO(HL 1,2 ) 2 ] (I-IV) (where acac = ( ); HL 1,2 = R′C(O)NHO − , R′ =-CH 2 OC 6 H 5 and-CH=CHC 6 H 5 ), have been synthesized by reaction of VO(acac) 2 with the potassium salt of phenoxyacetohydroxamic and cinnamohydroxamic acids and characterized by...

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Bibliographic Details
Published in:Journal of coordination chemistry 2010-06, Vol.63 (11), p.1940-1950
Main Authors: Sharma, Neeraj, Kumari, Meena, Kumar, Vijay, Chaudhry, S.C., Kanwar, S.S.
Format: Article
Language:English
Subjects:
Acids
Antibacterial activity
Antimicrobial activity
Cinnamohydroxamate
Drugs
Minimum inhibitory concentration
Molecular weight
Oxovanadium(IV) complexes
Potassium
Potassium phenoxyacetohydroxamate
Salts
Spectral studies
Streptomycin
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Summary:Vanadium(IV) complexes, [VO(acac)(HL 1,2 )] and [VO(HL 1,2 ) 2 ] (I-IV) (where acac = ( ); HL 1,2 = R′C(O)NHO − , R′ =-CH 2 OC 6 H 5 and-CH=CHC 6 H 5 ), have been synthesized by reaction of VO(acac) 2 with the potassium salt of phenoxyacetohydroxamic and cinnamohydroxamic acids and characterized by elemental analyses, molar conductivity, magnetic measurements, molecular weight determinations, IR, electronic, mass spectral, and electrochemical studies. From the spectroscopic studies, O,O coordination of hydroxamate ligands and a square-pyramidal geometry for the complexes has been proposed. The antibacterial activities of VO(acac) 2 , the precursor, the free ligands, and the synthesized oxovanadium(IV)hydroxamate complexes against six bacteria have been assayed by the minimum inhibitory concentration method. The complexes exhibit antimicrobial activities comparable to the standard drug streptomycin.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2010.495986