Nanostructured Materials for Skeletal Repair

The treatment of bone and cartilage defects with bioengineered constructs of artificial scaffolds and autogenous cells became the main challenge of contemporary regenerative medicine. Early defect repair may prevent secondary injury. Recent studies could prove that bone and cartilage cells are sensi...

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Bibliographic Details
Published in:Macromolecular symposia. 2010-08, Vol.294 (1), p.109-119
Main Authors: Brandt, Joerg, Michler, Goerg, Vogel, Juergen, Henning, Sven
Format: Article
Language:English
Subjects:
biomaterials
Bone healing
Cartilage
Cell adhesion
Extracellular matrix
Injuries
Macromolecules
Mimicry
nanofibres
Regeneration
scaffolds
tissue engineering scaffolds
Topography
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Summary:The treatment of bone and cartilage defects with bioengineered constructs of artificial scaffolds and autogenous cells became the main challenge of contemporary regenerative medicine. Early defect repair may prevent secondary injury. Recent studies could prove that bone and cartilage cells are sensitive to microscale and nanoscale patterns of surface topography and chemical structure. Nanostructured materials provide an environment for tissue regeneration mimicking the physiological range of extracellular matrix. The article reviews several studies substantiating the superiority of nanostructured materials for bone and cartilage repair along with own results on cell attachment.
ISSN:1022-1360
1521-3900
1521-3900
DOI:10.1002/masy.201050810