Cognitive function in 6- to 12-year-old offspring of women with Type1 diabetes

Aims Maternal diabetes is a recognized risk factor for congenital malformation, perinatal morbidity and obesity in later childhood. The aim of this study is to assess the impact of maternal diabetes on cognitive function in offspring. Methods Participants were 6- to 12-year-old offspring of women wi...

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Bibliographic Details
Published in:Diabetic medicine 2011-07, Vol.28 (7), p.845-848
Main Authors: Temple, R C, Hardiman, M, Pellegrini, M, Horrocks, L, Martinez-Cengotitabengoa, M-T
Format: Article
Language:English
Subjects:
Birth weight
Children
Cognitive ability
Congenital defects
Data processing
Diabetes mellitus
Gestational age
Hospitals
Infants
Intelligence
Memory
Morbidity
Obesity
Pregnancy
Progeny
Risk factors
Short term memory
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Summary:Aims Maternal diabetes is a recognized risk factor for congenital malformation, perinatal morbidity and obesity in later childhood. The aim of this study is to assess the impact of maternal diabetes on cognitive function in offspring. Methods Participants were 6- to 12-year-old offspring of women with Type1 diabetes. All women received their antenatal care and delivered at one university hospital. HbA1c was monitored monthly throughout pregnancy and cognitive function was assessed using the Wechsler Intelligence Scale for Children, version4. Results We present results in 40 offspring. There was no difference in overall full-scale IQ compared with UK normative data. However, working memory was poorer than other parts of the Wechsler Intelligence Scale for Children version4 test and significantly lower compared with UK normative data [8.4 (2.2) vs. 10.1 (3.2), P
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2011.03285.x