Texture direction of combined microgrooves and submicroscale topographies of titanium substrata influence adhesion, proliferation, and differentiation in human primary cells

Highlights ► Contact guidance is induced by submicroscale texture rather than by microgrooves. ► Acute angles between submicroscale texture and microgrooves trigger cell migration. ► Obtuse angles between submicro-texture and microgrooves discourage cell activities. ► Submicro-texture parallel with...

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Bibliographic Details
Published in:Archives of oral biology 2012-07, Vol.57 (7), p.898-905
Main Authors: Im, Byung Jin, Lee, Suk Won, Oh, Namsik, Lee, Myung Hyun, Kang, Jong Ho, Leesungbok, Richard, Lee, Sang Cheon, Ahn, Su Jin, Park, Jae Sang
Format: Article
Language:English
Subjects:
Advanced Basic Science
Alkaline Phosphatase - metabolism
Analysis of Variance
Cell Adhesion
Cell Differentiation
Cell Proliferation
Cells, Cultured
Dentistry
Fibroblasts - cytology
Fibroblasts - metabolism
Fibroblasts - ultrastructure
Gingiva - cytology
Gingiva - metabolism
Humans
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Microgrooves
Microscopy, Electron, Scanning
Osteoblast differentiation
Osteoblasts - cytology
Osteoblasts - metabolism
Periodontal Ligament - cytology
Periodontal Ligament - metabolism
Submicroscale texture
Surface Properties
Titanium - chemistry
Titanium substrata
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Description
Summary:Highlights ► Contact guidance is induced by submicroscale texture rather than by microgrooves. ► Acute angles between submicroscale texture and microgrooves trigger cell migration. ► Obtuse angles between submicro-texture and microgrooves discourage cell activities. ► Submicro-texture parallel with microgrooves enhance osteoblast differentiation. ► Earlier cell responses affect osteoblast differentiation but other factors exist.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2011.11.013