Insight into Amyloid Formation Using Congo Red as the Electrochemical Probe

The amyloid‐β (Aβ) aggregation pathway is an important target for the discovery of drugs that can prevent or delay the onset of Alzheimer’s disease (AD). The electrochemistry of Congo Red (CR) represents a particularly promising tool for screening of Aβ‐binding therapeutics in a rapid and cost‐effec...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2011-12, Vol.23 (12), p.2753-2756
Main Authors: Veloso, Anthony J., Chan, Tiffiny, Wing Sze Hung, Vinci, Lam, Leayen, Kerman, Kagan
Format: Article
Language:English
Subjects:
Agglomeration
Alzheimer's disease
Amyloid-β
Congo Red
Cyclic voltammetry
Delay
Monitoring
Oligomers
Screening
UV-vis spectroscopy
Voltammetry
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Summary:The amyloid‐β (Aβ) aggregation pathway is an important target for the discovery of drugs that can prevent or delay the onset of Alzheimer’s disease (AD). The electrochemistry of Congo Red (CR) represents a particularly promising tool for screening of Aβ‐binding therapeutics in a rapid and cost‐effective format. The results of the differential pulse voltammetry (DPV) measurements were confirmed using simultaneous UV‐vis analysis of the same incubated Aβ samples. The early changes in the electrochemical signals were attributed to the interaction of the Aβ oligomers with CR. The electrochemical approach, in principle, allowed monitoring small molecule‐Aβ interactions on the time scale of aggregation.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201100329