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Decidual vasculopathy and adverse perinatal outcome in preeclamptic pregnancy

Abstract Objective Decidual vasculopathy (DV) describes pathological findings seen in the spiral arteries in preeclampsia (PE). Morphologically, DV is characterized by fibrinoid necrosis and foamy macrophages within the vessel walls. The impact of the lesions on clinical outcome and placental pathol...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2012-08, Vol.33 (8), p.630-633
Main Authors: Stevens, D.U, Al-Nasiry, S, Bulten, J, Spaanderman, M.E.A
Format: Article
Language:English
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Summary:Abstract Objective Decidual vasculopathy (DV) describes pathological findings seen in the spiral arteries in preeclampsia (PE). Morphologically, DV is characterized by fibrinoid necrosis and foamy macrophages within the vessel walls. The impact of the lesions on clinical outcome and placental pathology is unclear. We compared cases with DV to cases without these lesions on clinical outcome and placental histology in PE. Study design Placental sections from 107 patients admitted with PE at the Radboud University Nijmegen Medical Centre, during the years 1995–2000, were analyzed. 25 cases were excluded due to incomplete records or multiple pregnancy. Cases with DV ( n  = 41) and without DV ( n  = 41) were compared for various clinical and placental histological parameters, using Mann–Whitney test. P -value 
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2012.04.013