Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs

A methanol extract of the twigs of Cinnamomum cassia was found to inhibit xanthine oxidase. Purification of the methanol extract afforded three new phenolic glycosides, cinnacasolide A–C (11–13), together with 10 known compounds (1–10). The structures of the three new compounds were determined by in...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2012-07, Vol.22 (14), p.4625-4628
Main Authors: Ngoc, Tran Minh, Khoi, Nguyen Minh, Ha, Do Thi, Nhiem, Nguyen Xuan, Tai, Bui Huu, Don, Dao Van, Luong, Hoang Van, Son, Doan Cao, Bae, KiHwan
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cinnacasolide
Cinnamaldehyde derivatives
Cinnamomum aromaticum - chemistry
Cinnamomum cassia
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
General pharmacology
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Structure-Activity Relationship
Xanthine Oxidase - antagonists & inhibitors
Xanthine oxidase inhibitor
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Summary:A methanol extract of the twigs of Cinnamomum cassia was found to inhibit xanthine oxidase. Purification of the methanol extract afforded three new phenolic glycosides, cinnacasolide A–C (11–13), together with 10 known compounds (1–10). The structures of the three new compounds were determined by interpretation of spectroscopic data. Cinnamaldehyde derivatives 1−5 and 7 were significant inhibitors of xanthine oxidase, with IC50 values ranging from 7.8 to 36.3μg/mL. The results indicate that the acyl group of these cinnamaldehyde derivatives plays an important role in the inhibition of xanthine oxidase.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2012.05.051