Cristatumins A–D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220

Four new indole alkaloids, namely, cristatumins A–D (1–4), along with six known congeners (5–10) were identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus isolated from the marine alga Sargassum thunbergii. The structures of these compounds were established on the b...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2012-07, Vol.22 (14), p.4650-4653
Main Authors: Du, Feng-Yu, Li, Xiao-Ming, Li, Chun-Shun, Shang, Zhuo, Wang, Bin-Gui
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antibacterial properties
Antimicrobial activity
Artemia
Biological and medical sciences
Brine shrimp inhibition
endophytes
Escherichia coli
Escherichia coli - drug effects
Eurotium
Eurotium - chemistry
Eurotium cristatum
fungi
Indole alkaloid
indole alkaloids
Indole Alkaloids - chemistry
Indole Alkaloids - pharmacology
insecticidal properties
Marine endophyte
Medical sciences
Models, Molecular
Molecular Structure
Pharmacology. Drug treatments
Sargassum thunbergii
spectroscopy
Staphylococcus aureus
Staphylococcus aureus - drug effects
Structure-Activity Relationship
structure-activity relationships
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Summary:Four new indole alkaloids, namely, cristatumins A–D (1–4), along with six known congeners (5–10) were identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus isolated from the marine alga Sargassum thunbergii. The structures of these compounds were established on the basis of extensive spectroscopic analysis. Each of these compounds was evaluated for antimicrobial and insecticidal activity. Compounds 1 and 9 showed antibacterial activity against Escherichia coli and Staphyloccocus aureus, respectively, while compounds 2, 6, and 7 exhibited moderate lethal activity against brine shrimp. Preliminary structure–activity relationships were also discussed.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2012.05.088