Thymic Neoplasms: a Clinical Update

Thymoma is a unique neoplasm of the anterior mediastinum that is frequently associated with indolent growth and a variety of paraneoplastic syndromes. One third of cases are detected during the evaluation of myasthenia gravis. Classification systems of thymoma have limited ability in accurately pred...

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Bibliographic Details
Published in:Current oncology reports 2012-08, Vol.14 (4), p.350-358
Main Authors: Mikhail, Mark, Mekhail, Yasmin, Mekhail, Tarek
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Chemotherapy, Adjuvant
Humans
Lung Cancer (T Mekhail
Medicine
Medicine & Public Health
Neoplasm Staging
Oncology
Radiotherapy, Adjuvant
Section Editor
Thymoma - diagnosis
Thymoma - pathology
Thymoma - therapy
Thymus Neoplasms - diagnosis
Thymus Neoplasms - pathology
Thymus Neoplasms - therapy
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Summary:Thymoma is a unique neoplasm of the anterior mediastinum that is frequently associated with indolent growth and a variety of paraneoplastic syndromes. One third of cases are detected during the evaluation of myasthenia gravis. Classification systems of thymoma have limited ability in accurately predicting prognosis and course of disease. Thus, staging is the only way to predict clinical behavior. Encapsulated tumors that are surgically resected carry the best prognosis. Adjuvant radiotherapy is recommended for incompletely excised and most invasive thymomas. Chemotherapy in anthracycline-based chemotherapy remains the most effective chemotherapy for neoadjuvant, adjuvant or palliative treatment.
ISSN:1523-3790
1534-6269
DOI:10.1007/s11912-012-0246-8