Pharmacokinetics of oral meloxicam in ruminant and preruminant calves

Mosher, R. A., Coetzee, J. F., Cull, C. A., Gehring, R., KuKanich, B. Pharmacokinetics of oral meloxicam in ruminant and preruminant calves. J. vet. Pharmacol. Therap. 35, 373–381. The pharmacokinetics of oral meloxicam has been studied in ruminant, but not preruminant calves. Oral meloxicam was adm...

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Published in:Journal of veterinary pharmacology and therapeutics 2012-08, Vol.35 (4), p.373-381
Main Authors: MOSHER, R. A, COETZEE, J. F, CULL, C. A, GEHRING, R, KuKANICH, B
Format: Article
Language:English
Subjects:
Absorption
Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal - blood
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Area Under Curve
bioavailability
calves
Cattle
Digestion - physiology
gastrointestinal system
Half-Life
Male
meloxicam
milk replacer
pharmacokinetics
Thiazines - blood
Thiazines - pharmacokinetics
Thiazoles - blood
Thiazoles - pharmacokinetics
Weaning
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Summary:Mosher, R. A., Coetzee, J. F., Cull, C. A., Gehring, R., KuKanich, B. Pharmacokinetics of oral meloxicam in ruminant and preruminant calves. J. vet. Pharmacol. Therap. 35, 373–381. The pharmacokinetics of oral meloxicam has been studied in ruminant, but not preruminant calves. Oral meloxicam was administered at 0.5 mg/kg to six ruminant calves via gavage (RG); to six preruminant calves via gavage (PRG); and to six preruminant calves via suckling in milk replacer (PRF). Plasma drug concentrations, determined over 120‐h postadministration, were analyzed by compartmental and noncompartmental methods. The rate of drug absorption was faster (P 
ISSN:0140-7783
1365-2885
DOI:10.1111/j.1365-2885.2011.01331.x