The difference of glucostatic parameters according to the remission of diabetes after Roux-en-Y gastric bypass

Background Gut hormones play a role in diabetes remission after a Roux‐en‐Y gastric bypass (RYGB). Our aim was to investigate differences in gut hormone secretion according to diabetes remission after surgery. Second, we aimed to identify differences in insulin secretion and sensitivity according to...

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Bibliographic Details
Published in:Diabetes/metabolism research and reviews 2012-07, Vol.28 (5), p.439-446
Main Authors: Kim, Mee Kyoung, Lee, Hong Chan, Lee, Seung Hwan, Kwon, Hyuk-Sang, Baek, Ki-Hyun, Kim, Eung Kook, Lee, Kwang Woo, Song, Ki-Ho
Format: Article
Language:English
Subjects:
Adult
bariatric surgery
Blood Glucose - metabolism
C-Peptide - metabolism
Case-Control Studies
Diabetes Complications - metabolism
Diabetes Complications - prevention & control
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - surgery
Female
Gastric Bypass
GLP-1
Glucagon-Like Peptide 1 - metabolism
Glucose Tolerance Test
Humans
Hyperinsulinism - metabolism
Hyperinsulinism - prevention & control
Insulin - metabolism
Insulin Resistance
Insulin-Secreting Cells - metabolism
Male
Middle Aged
Obesity - blood
Obesity - surgery
Prognosis
Prospective Studies
Remission Induction
remission of diabetes
Young Adult
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Summary:Background Gut hormones play a role in diabetes remission after a Roux‐en‐Y gastric bypass (RYGB). Our aim was to investigate differences in gut hormone secretion according to diabetes remission after surgery. Second, we aimed to identify differences in insulin secretion and sensitivity according to diabetes remission after RYGB. Methods Twenty‐two severely obese patients with type 2 diabetes underwent RYGB. A meal tolerance test (MTT) was performed 12 months after RYGB. The secretions of active glucagon‐like peptide‐1 (active GLP‐1), glucose‐dependent insulinotropic peptide (GIP), peptide YY, C‐peptide and insulin during the MTT test were calculated using total area under the curve values (AUC). Remission was defined as glycated haemoglobin (A1C) of
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.2297