Breast cancer risk factors: a comparison between pre-menopausal and post-menopausal women

To evaluate the difference between pre- and post-menopausal breast cancer regarding menstrual and reproductive risk factors The case-control study was conducted in Mayo Hospital, Lahore, between October 2008 and April 2009. Cases were breast cancer patients admitted in the surgical and oncology floo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2012-02, Vol.62 (2), p.120-124
Main Authors: Butt, Zeeshan, Haider, Syed Furqan, Arif, Shumaila, Khan, Muhammad Raza, Ashfaq, Umair, Shahbaz, Umer, Bukhari, Mulazam Hussain
Format: Article
Language:English
Subjects:
Adult
Age Factors
Breast cancer
Breast Neoplasms - epidemiology
Case-Control Studies
Demographic aspects
Female
Health aspects
Humans
Middle Aged
Pakistan
Postmenopausal women
Postmenopause
Premenopause
Reproductive health
Reproductive History
Risk Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate the difference between pre- and post-menopausal breast cancer regarding menstrual and reproductive risk factors The case-control study was conducted in Mayo Hospital, Lahore, between October 2008 and April 2009. Cases were breast cancer patients admitted in the surgical and oncology floors of the hospital. Controls were hospital patients without breast cancer. The study enrolled 150 cases and 300 controls. Menstrual and reproductive history was taken from both the cases and the controls. For every risk factor age-adjusted odds ratio (OR) and 95% confidence interval (CI) was calculated by logistic regression analysis, separate for pre- and post-menopausal women. Among the breast cancer patients, 42.7% were pre-menopausal and 57.3% were post-menopausal. Age at menarche had no association with breast cancer for both pre- and post-menopausal women. Nulliparity was a risk factor for both pre-menopausal (OR 4.1, 95% CI 1.4-12.6) and post-menopausal breast cancer (OR 8.2, 95% CI 1.7-40.4). Among parous women only post-menopausal females having < 3 children were at increased risk for breast cancer (OR 4.5, 95% CI 1.8-11.5) compared with females having > or = 3 children. Younger age at first live birth decreased breast cancer risk in both pre- and post-menopausal women. Breastfeeding was not associated with both pre- and post-menopausal breast cancer. Majority of risk factors for pre-menopausal breast cancer are also associated with postmenopausal breast cancer except less parity, which increased the risk for post-menopausal breast cancer only.
ISSN:0030-9982