Copper-Catalyzed Aerobic Spirocyclization of Biaryl-N-H-imines via 1,4-Aminooxygenation of Benzene Rings

A synthetic method of azaspirocyclohexadienones has been developed through copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines prepared by the reaction of biarylcarbonitriles and Grignard reagents.

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Bibliographic Details
Published in:Organic letters 2012-07, Vol.14 (13), p.3550-3553
Main Authors: Tnay, Ya Lin, Chen, Cheng, Chua, Yi Yuan, Zhang, Line, Chiba, Shunsuke
Format: Article
Language:English
Subjects:
Aza Compounds - chemistry
Catalysis
Copper - chemistry
Cyclization
Cyclohexenes - chemistry
Imines - chemical synthesis
Imines - chemistry
Molecular Conformation
Organometallic Compounds - chemistry
Oxygen - chemistry
Spiro Compounds - chemistry
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Description
Summary:A synthetic method of azaspirocyclohexadienones has been developed through copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines prepared by the reaction of biarylcarbonitriles and Grignard reagents.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol301583y