New targets for acetylation in autophagy

Macroautophagy is an evolutionarily conserved homeostatic process that mediates the degradation of long-lived cytoplasmic components in eukaryotes, which allows cells to survive stresses such as inflammation, hypoxia, and deprivation of nutrients or growth factors. At least 30 members of the Atg (au...

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Bibliographic Details
Published in:Science signaling 2012-07, Vol.5 (231), p.pe29-pe29
Main Authors: Hamaï, Ahmed, Codogno, Patrice
Format: Article
Language:English
Subjects:
Acetylation
Animals
Autophagy
Humans
Protein Processing, Post-Translational
Signal Transduction
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Summary:Macroautophagy is an evolutionarily conserved homeostatic process that mediates the degradation of long-lived cytoplasmic components in eukaryotes, which allows cells to survive stresses such as inflammation, hypoxia, and deprivation of nutrients or growth factors. At least 30 members of the Atg (autophagy-related) protein family orchestrate this degradative process. Additional complexity resides in the signaling networks controlling the autophagic process, which include various posttranslational modifications of key components. Evidence is accumulating that protein acetylation represents an evolutionarily conserved mechanism tightly regulating macroautophagy.
ISSN:1945-0877
1937-9145
DOI:10.1126/scisignal.2003187