Inversion and crossover recombination contributions to the spacing between two functionally linked genes

The roles of inversion and crossover recombination in determining the spacing between two functionally linked genes on an individual strand of DNA and the resulting genetic organization throughout the population is not well understood. We employ a computer simulation to look at the spacing between f...

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Bibliographic Details
Published in:BioSystems 2012-08, Vol.109 (2), p.169-178
Main Authors: Clark, B.K., Wabick, K.J., Weidner, J.G.
Format: Article
Language:English
Subjects:
Chromosome Inversion
Computer Simulation
Crossing Over, Genetic
Crossover
Functional linkage
Genetic Linkage
Inversion
Recombination
Recombination, Genetic
Structural linkage
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Summary:The roles of inversion and crossover recombination in determining the spacing between two functionally linked genes on an individual strand of DNA and the resulting genetic organization throughout the population is not well understood. We employ a computer simulation to look at the spacing between functionally linked genes after many generations of a population of haploid individuals, each with a single chromosome. Simulations show that inversion and crossover recombination combine to create four attractors in gene spacing. The two major attractors include one in which the linked genes are forced to be near each other and one in which the linked genes are forced to be separated by one third of the chromosome length. Multiplicative functional linkage between two linked genes also causes a decreased average spacing compared to additive and random functional linkage.
ISSN:0303-2647
1872-8324
DOI:10.1016/j.biosystems.2012.04.013