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Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications
Silicon nanoparticles (SiNPs) obtained by mechanical grinding of porous silicon have been used for visualization of living cells in vitro. It was found that SiNPs could penetrate into the cells without any cytotoxic effect up to the concentration of 100 μg/ml. The cell cytoplasm was observed to be f...
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| Published in: | Journal of biophotonics 2012-07, Vol.5 (7), p.529-535 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4232-1f6c3f4a99bb3deb5f4de1d79545db978ff5dc05643788622b29585f54f3b3173 |
| container_end_page | 535 |
| container_issue | 7 |
| container_start_page | 529 |
| container_title | Journal of biophotonics |
| container_volume | 5 |
| creator | Osminkina, Liubov A. Tamarov, Konstantin P. Sviridov, Andrey P. Galkin, Rostislav A. Gongalsky, Maxim B. Solovyev, Valery V. Kudryavtsev, Andrey A. Timoshenko, Victor Yu |
| description | Silicon nanoparticles (SiNPs) obtained by mechanical grinding of porous silicon have been used for visualization of living cells in vitro. It was found that SiNPs could penetrate into the cells without any cytotoxic effect up to the concentration of 100 μg/ml. The cell cytoplasm was observed to be filled by SiNPs, which exhibited bright photoluminescence at 1.6 eV. SiNPs could also act as photosensitizers of the singlet oxygen generation, which could be used in the photodynamic therapy of cancer. These properties of SiNPs are discussed in view of possible applications in theranostics (both in therapy and in diagnostics). (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) |
| doi_str_mv | 10.1002/jbio.201100112 |
| format | article |
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KGaA, Weinheim)</description><subject>Animals</subject><subject>bio-imaging</subject><subject>biocompatible</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - radiation effects</subject><subject>Dogs</subject><subject>Hep G2 Cells</subject><subject>Humans</subject><subject>Luminescent Agents - chemistry</subject><subject>Luminescent Agents - pharmacology</subject><subject>Luminescent Agents - therapeutic use</subject><subject>Luminescent Measurements</subject><subject>Mechanical Phenomena</subject><subject>Metal Nanoparticles</subject><subject>Mice</subject><subject>Molecular Imaging</subject><subject>Nanotechnology</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>NIH 3T3 Cells</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>porous silicon</subject><subject>Silicon - chemistry</subject><subject>Silicon - pharmacology</subject><subject>Silicon - therapeutic use</subject><subject>silicon nanoparticles</subject><subject>Singlet Oxygen - metabolism</subject><subject>theranostics of cancer</subject><subject>Water - chemistry</subject><issn>1864-063X</issn><issn>1864-0648</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkDtPwzAURi0EorxWRpSRJcXvJCNviipACEQ3y3Zs1ZDEwU4F_HuMWio2Jl_rnu9I9wPgEMExghCfvCrnxxii9EEIb4AdVHKaQ07LzfVMZiOwG-MrhBwSRrbBCGNKSoKKHTB7mPvBN4vWdSZq0w1ZEmrf9nJwqjFZdI3Tvss62flehsHpxsTM-pBp2WkTsmFuQtrFtMlk3yc6JX0X98GWlU00B6t3DzxfXT6d3-TT--vJ-ek01xQTnCPLNbFUVpVSpDaKWVobVBcVo6xWVVFay2oNGaekKEuOscIVK5ll1BKVLiB74Hjp7YN_X5g4iNalQ5pGdsYvokAQU1pwjlFCx0tUBx9jMFb0wbUyfCVI_LQpftoU6zZT4GjlXqjW1Gv8t74EVEvgwzXm6x-duD2b3P-V58usi4P5XGdleBO8IAUTL3fX4u6KnMHHiwtByDfI0JHi</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Osminkina, Liubov A.</creator><creator>Tamarov, Konstantin P.</creator><creator>Sviridov, Andrey P.</creator><creator>Galkin, Rostislav A.</creator><creator>Gongalsky, Maxim B.</creator><creator>Solovyev, Valery V.</creator><creator>Kudryavtsev, Andrey A.</creator><creator>Timoshenko, Victor Yu</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201207</creationdate><title>Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications</title><author>Osminkina, Liubov A. ; 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| subjects | Animals bio-imaging biocompatible Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biocompatible Materials - therapeutic use Cell Survival - drug effects Cell Survival - radiation effects Dogs Hep G2 Cells Humans Luminescent Agents - chemistry Luminescent Agents - pharmacology Luminescent Agents - therapeutic use Luminescent Measurements Mechanical Phenomena Metal Nanoparticles Mice Molecular Imaging Nanotechnology Neoplasms - diagnosis Neoplasms - pathology Neoplasms - therapy NIH 3T3 Cells Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use porous silicon Silicon - chemistry Silicon - pharmacology Silicon - therapeutic use silicon nanoparticles Singlet Oxygen - metabolism theranostics of cancer Water - chemistry |
| title | Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications |
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