Lack of association of CYP1A1-MspI SNP and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence

Research has shown that genetic polymorphisms in biotransformation enzymes, such as CYP1A1 and GSTM1, are related to a greater or lesser susceptibility to various cancers. We made an analysis of CYP1A1m1 SNP and GSTM1 null genotypes in a family group (71 members) related by consanguinity who had an...

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Bibliographic Details
Published in:Genetics and molecular research 2012-01, Vol.11 (2), p.1610-1617
Main Authors: Moraes, L N, Borges, M F, Sousa, P A C, Venere, P C, Souza, I L
Format: Article
Language:English
Subjects:
Brazil
Cytochrome P-450 CYP1A1 - genetics
Female
Genetic Predisposition to Disease - genetics
Glutathione Transferase - genetics
Humans
Male
Neoplasms - genetics
Pedigree
Polymorphism, Single Nucleotide - genetics
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Summary:Research has shown that genetic polymorphisms in biotransformation enzymes, such as CYP1A1 and GSTM1, are related to a greater or lesser susceptibility to various cancers. We made an analysis of CYP1A1m1 SNP and GSTM1 null genotypes in a family group (71 members) related by consanguinity who had an unusually high incidence of cancer and a high frequency of smokers. There were no significant differences in genotype frequencies in this family when compared to data for Brazilian populations. Possibly, the high incidence of cancer in this sample is associated with smoking and/or other factors not detected in this survey.
ISSN:1676-5680
1676-5680
DOI:10.4238/2012.June.15.10