2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

A study investigated the solution-phase synthesis of 2,5-diketopiperazines, focusing on its molecular and chemical structures. Researchers made use of nuclear magnetic resonance (NMR) to study the synthesis, reactions and chemistry of 2-5-diketopiperazines.

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Bibliographic Details
Published in:Chemical reviews 2012-07, Vol.112 (7), p.3641-3716
Main Author: Borthwick, Alan D
Format: Article
Language:English
Subjects:
Animals
Biological Products - chemical synthesis
Biological Products - chemistry
Biological Products - pharmacology
Catalysis
Cell Line, Tumor
Chemical reactions
Chemical synthesis
Chemistry Techniques, Synthetic - methods
Chemistry, Pharmaceutical - methods
Crystal structure
Diketopiperazines - chemical synthesis
Diketopiperazines - chemistry
Diketopiperazines - pharmacology
Humans
Molecular structure
Natural products
NMR
Nuclear magnetic resonance
Peptides
Peptidomimetics - chemical synthesis
Peptidomimetics - chemistry
Peptidomimetics - pharmacology
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Description
Summary:A study investigated the solution-phase synthesis of 2,5-diketopiperazines, focusing on its molecular and chemical structures. Researchers made use of nuclear magnetic resonance (NMR) to study the synthesis, reactions and chemistry of 2-5-diketopiperazines.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr200398y