Infection by Cag A Positive Strains of Helicobacter pylori is Associated with Autoimmune Thyroid Disease in Iranian Patients

Background: Infectious agents have been suspected as a triggering factor for development of autoimmune thyroid disease (ATD). Some reports from Western countries have suggested association between Helicobacter pylori (HP) infection and ATD. Objective: To investigate the association of ATD with Cag A...

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Published in:Iranian journal of immunology 2012-03, Vol.9 (1), p.1-1
Main Authors: Soveid, Mahmood, Asl, Kazem Hosseini, Omrani, Gholamhossein Ranjbar
Format: Article
Language:English
Subjects:
Age
Antigens
Helicobacter pylori
Hypothyroidism
Immunoglobulin G
Immunoglobulins
Infection
Infections
Population
Studies
Thyroid diseases
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container_title Iranian journal of immunology
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creator Soveid, Mahmood
Asl, Kazem Hosseini
Omrani, Gholamhossein Ranjbar
description Background: Infectious agents have been suspected as a triggering factor for development of autoimmune thyroid disease (ATD). Some reports from Western countries have suggested association between Helicobacter pylori (HP) infection and ATD. Objective: To investigate the association of ATD with Cag A seropositivity in a population with high rate and early age of onset of HP infection. Methods: IgG anti HP and anti Cag A antibodies were measured in 88 patients with ATD and compared with results of 112 healthy individuals. Results: The rate of infection with HP was not significantly different in patient and control groups, but there was significant association between ATD and infection with Cag A strains (p
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Some reports from Western countries have suggested association between Helicobacter pylori (HP) infection and ATD. Objective: To investigate the association of ATD with Cag A seropositivity in a population with high rate and early age of onset of HP infection. Methods: IgG anti HP and anti Cag A antibodies were measured in 88 patients with ATD and compared with results of 112 healthy individuals. Results: The rate of infection with HP was not significantly different in patient and control groups, but there was significant association between ATD and infection with Cag A strains (p&lt;0.005). This association was significant for both hypothyroidism (p&lt;0.005) and Graves' disease (p&lt;0.02). Cag A antibody level correlated with titers of thyroid auto antibodies (p&lt;0.001). 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Some reports from Western countries have suggested association between Helicobacter pylori (HP) infection and ATD. Objective: To investigate the association of ATD with Cag A seropositivity in a population with high rate and early age of onset of HP infection. Methods: IgG anti HP and anti Cag A antibodies were measured in 88 patients with ATD and compared with results of 112 healthy individuals. Results: The rate of infection with HP was not significantly different in patient and control groups, but there was significant association between ATD and infection with Cag A strains (p&lt;0.005). This association was significant for both hypothyroidism (p&lt;0.005) and Graves' disease (p&lt;0.02). Cag A antibody level correlated with titers of thyroid auto antibodies (p&lt;0.001). 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subjects Age
Antigens
Helicobacter pylori
Hypothyroidism
Immunoglobulin G
Immunoglobulins
Infection
Infections
Population
Studies
Thyroid diseases
title Infection by Cag A Positive Strains of Helicobacter pylori is Associated with Autoimmune Thyroid Disease in Iranian Patients
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