High genetic diversity of Staphylococcus aureus strains colonizing patients with epidermolysis bullosa

Patients with the blistering disease, epidermolysis bullosa (EB), frequently suffer from chronic wounds that become colonized by pathogenic bacteria, such as Staphylococcus aureus. To determine S. aureus colonization rates in patients with EB, swabs were collected from the anterior nares, throats an...

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Bibliographic Details
Published in:Experimental dermatology 2012-06, Vol.21 (6), p.463-466
Main Authors: van der Kooi-Pol, Magdalena M., Veenstra-Kyuchukova, Yanka K., Duipmans, José C., Pluister, Gerlinde N., Schouls, Leo M., de Neeling, Albert J., Grundmann, Hajo, Jonkman, Marcel F., van Dijl, Jan Maarten
Format: Article
Language:English
Subjects:
Bacterial diseases
Biological and medical sciences
Bullous diseases of the skin
Colonization
Dermatology
Epidermolysis bullosa
Epidermolysis Bullosa - complications
Epidermolysis Bullosa - microbiology
Genetic diversity
Genetic Variation
Human bacterial diseases
Humans
Infectious diseases
Medical personnel
Medical sciences
multiple-locus variable number of tandem repeats analysis
nasal colonization
Pharynx
spa typing
Staphylococcal Infections - microbiology
Staphylococcal Infections - transmission
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Staphylococcus aureus - genetics
Staphylococcus aureus - isolation & purification
Typing
wound colonization
Wounds
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Summary:Patients with the blistering disease, epidermolysis bullosa (EB), frequently suffer from chronic wounds that become colonized by pathogenic bacteria, such as Staphylococcus aureus. To determine S. aureus colonization rates in patients with EB, swabs were collected from the anterior nares, throats and wounds of 52 Dutch patients with EB. Swabs were also collected from nares and throats of 13 healthcare workers who occasionally meet the sampled patients with EB. All EB patients with chronic wounds and 75% of the patients without chronic wounds were colonized with S. aureus. In contrast, 39% of the sampled healthcare workers were colonized with S. aureus. Typing revealed a high degree of genetic diversity of 184 collected S. aureus isolates. Autoinoculation of S. aureus in individual patients with EB was shown to occur frequently, whereas transmission of S. aureus between patients with EB is apparently rare. There was no evidence for S. aureus transmission between patients with EB and healthcare workers.
ISSN:0906-6705
1600-0625
DOI:10.1111/j.1600-0625.2012.01502.x