Past decade study of snake venom l-amino acid oxidase

As one of the major protein (enzyme) components of snake venom (SV), l-amino acid oxidase (LAAO) plays an important role in the toxicities and biological activities for SV. Accumulated researches in the past decade gradually revealed that SV-LAAOs induce platelet aggregation, cell apoptosis and cyto...

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Bibliographic Details
Published in:Toxicon (Oxford) 2012-09, Vol.60 (3), p.302-311
Main Authors: Guo, Chunmei, Liu, Shuqing, Yao, Yiwen, Zhang, Qiaoqiao, Sun, Ming-Zhong
Format: Article
Language:English
Subjects:
amino acids
Animal poisons toxicology. Antivenoms
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - metabolism
Anti-Infective Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
antiretroviral agents
apoptosis
Apoptosis - drug effects
Biological activities
Biological and medical sciences
Coagulants - chemistry
Coagulants - metabolism
Coagulants - pharmacology
cytotoxicity
Drug Discovery
Glycoproteins - chemistry
Glycoproteins - metabolism
Glycoproteins - pharmacology
Human immunodeficiency virus
Humans
l-amino acid oxidase
L-Amino Acid Oxidase - chemistry
L-Amino Acid Oxidase - metabolism
L-Amino Acid Oxidase - pharmacology
mechanism of action
Medical sciences
Metalloproteins - chemistry
Metalloproteins - metabolism
Metalloproteins - pharmacology
platelet aggregation
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - chemistry
Platelet Aggregation Inhibitors - metabolism
Platelet Aggregation Inhibitors - pharmacology
Protein Conformation
Reptilian Proteins - chemistry
Reptilian Proteins - metabolism
Reptilian Proteins - pharmacology
Snake venom
Snake Venoms - enzymology
snakes
Toxicology
venoms
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Summary:As one of the major protein (enzyme) components of snake venom (SV), l-amino acid oxidase (LAAO) plays an important role in the toxicities and biological activities for SV. Accumulated researches in the past decade gradually revealed that SV-LAAOs induce platelet aggregation, cell apoptosis and cytotoxicity, and have anti-microbial, anti-leishmaniasis, anti-tumor and anti-HIV activity. Except for the enzymatic and structural characteristics of SV-LAAOs, the biological functions of SV-LAAOs and relevant action mechanisms are also summarized and discussed in the review. This work might provide useful inputs for future studies on SV-LAAOs.
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2012.05.001