Piperine suppresses cerebral ischemia–reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model

The pathophysiological mechanisms leading to neuronal injury in middle cerebral artery occlusion (MCAO) model of cerebral stroke are complex and multifactorial that form the bases of behavioral deficits and inflammation mediated damage. The present study demonstrates the effect of piperine pretreatm...

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Published in:Molecular and cellular biochemistry 2012-08, Vol.367 (1-2), p.73-84
Main Authors: Vaibhav, Kumar, Shrivastava, Pallavi, Javed, Hayate, Khan, Andleeb, Ahmed, Md. Ejaz, Tabassum, Rizwana, Khan, Mohd. Moshahid, Khuwaja, Gulrana, Islam, Farah, Saeed Siddiqui, M., Safhi, Mohammed M., Islam, Fakhrul
Format: Article
Language:English
Subjects:
Alkaloids - pharmacology
Animals
Anti-Inflammatory Agents - pharmacology
Antiinflammatory agents
Benzodioxoles - pharmacology
Biochemistry
Biomedical and Life Sciences
Brain
Cardiology
Cell death
Cerebral blood flow
Cyclooxygenase 2 - genetics
Cyclooxygenase 2 - metabolism
Cyclooxygenase-2
Cytokines - blood
Cytokines - secretion
Down-Regulation - drug effects
Infarction, Middle Cerebral Artery - complications
Infarction, Middle Cerebral Artery - drug therapy
Infarction, Middle Cerebral Artery - pathology
Inflammation
Inflammation Mediators - blood
Injuries
Interleukin 1
Interleukin 6
Ischemia
Life Sciences
Male
Medical Biochemistry
Motor Activity - drug effects
Muscle Strength - drug effects
Neurons
Neuroprotective Agents - pharmacology
NF- Kappa B protein
NF-kappa B - genetics
NF-kappa B - metabolism
Nitric Oxide Synthase Type II - genetics
Nitric Oxide Synthase Type II - metabolism
Oncology
Piperidines - pharmacology
Polyunsaturated Alkamides - pharmacology
Rats
Rats, Wistar
Reperfusion
Reperfusion Injury - etiology
Reperfusion Injury - pathology
Reperfusion Injury - prevention & control
Stroke
Tumor necrosis factor- alpha
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Summary:The pathophysiological mechanisms leading to neuronal injury in middle cerebral artery occlusion (MCAO) model of cerebral stroke are complex and multifactorial that form the bases of behavioral deficits and inflammation mediated damage. The present study demonstrates the effect of piperine pretreatment (10 mg/kg b wt, once daily p.o . for 15 days) on cerebral ischemia-induced inflammation in male Wistar rats. The right middle cerebral artery was occluded for 2 h followed by reperfusion for 22 h. A maximum infarct volume (57.80 %) was observed in ischemic MCAO group. However, piperine administration prior to ischemia showed a significant reduction in infarct volume (28.29 %; p  
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-012-1321-z