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Piperine suppresses cerebral ischemia–reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model
The pathophysiological mechanisms leading to neuronal injury in middle cerebral artery occlusion (MCAO) model of cerebral stroke are complex and multifactorial that form the bases of behavioral deficits and inflammation mediated damage. The present study demonstrates the effect of piperine pretreatm...
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| Published in: | Molecular and cellular biochemistry 2012-08, Vol.367 (1-2), p.73-84 |
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| container_end_page | 84 |
| container_issue | 1-2 |
| container_start_page | 73 |
| container_title | Molecular and cellular biochemistry |
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| creator | Vaibhav, Kumar Shrivastava, Pallavi Javed, Hayate Khan, Andleeb Ahmed, Md. Ejaz Tabassum, Rizwana Khan, Mohd. Moshahid Khuwaja, Gulrana Islam, Farah Saeed Siddiqui, M. Safhi, Mohammed M. Islam, Fakhrul |
| description | The pathophysiological mechanisms leading to neuronal injury in middle cerebral artery occlusion (MCAO) model of cerebral stroke are complex and multifactorial that form the bases of behavioral deficits and inflammation mediated damage. The present study demonstrates the effect of piperine pretreatment (10 mg/kg b wt, once daily p.o
.
for 15 days) on cerebral ischemia-induced inflammation in male Wistar rats. The right middle cerebral artery was occluded for 2 h followed by reperfusion for 22 h. A maximum infarct volume (57.80 %) was observed in ischemic MCAO group. However, piperine administration prior to ischemia showed a significant reduction in infarct volume (28.29 %;
p
|
| doi_str_mv | 10.1007/s11010-012-1321-z |
| format | article |
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.
for 15 days) on cerebral ischemia-induced inflammation in male Wistar rats. The right middle cerebral artery was occluded for 2 h followed by reperfusion for 22 h. A maximum infarct volume (57.80 %) was observed in ischemic MCAO group. However, piperine administration prior to ischemia showed a significant reduction in infarct volume (28.29 %;
p
< 0.05) and neuronal loss (12.72 %;
p
< 0.01). As a result of piperine pretreatment, a significant improvement in behavioral outputs of MCAO rats (
p
< 0.05–0.01) was observed. Piperine successfully reduced the level of proinflammatory cytokines IL-1β, IL-6 and TNF-α, in ischemic group (
p
< 0.01). Ischemic group brain has shown edematous morphology with vacuolated architecture and pyknotic nuclei in H & E staining which was successfully ameliorated by piperine administration. Moreover, piperine also succeeded in lowering the expression of COX-2, NOS-2, and NF-κB (
p
< 0.01). Both cytosolic and nuclear NF-κB were down-regulated in ischemic group pre-administered with piperine (
p
< 0.01). The present study suggests that piperine is able to salvage the ischemic penumbral zone neurons by virtue of its anti-inflammatory property, thereby limiting ischemic cell death.]]></description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-012-1321-z</identifier><identifier>PMID: 22669728</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Alkaloids - pharmacology ; Animals ; Anti-Inflammatory Agents - pharmacology ; Antiinflammatory agents ; Benzodioxoles - pharmacology ; Biochemistry ; Biomedical and Life Sciences ; Brain ; Cardiology ; Cell death ; Cerebral blood flow ; Cyclooxygenase 2 - genetics ; Cyclooxygenase 2 - metabolism ; Cyclooxygenase-2 ; Cytokines - blood ; Cytokines - secretion ; Down-Regulation - drug effects ; Infarction, Middle Cerebral Artery - complications ; Infarction, Middle Cerebral Artery - drug therapy ; Infarction, Middle Cerebral Artery - pathology ; Inflammation ; Inflammation Mediators - blood ; Injuries ; Interleukin 1 ; Interleukin 6 ; Ischemia ; Life Sciences ; Male ; Medical Biochemistry ; Motor Activity - drug effects ; Muscle Strength - drug effects ; Neurons ; Neuroprotective Agents - pharmacology ; NF- Kappa B protein ; NF-kappa B - genetics ; NF-kappa B - metabolism ; Nitric Oxide Synthase Type II - genetics ; Nitric Oxide Synthase Type II - metabolism ; Oncology ; Piperidines - pharmacology ; Polyunsaturated Alkamides - pharmacology ; Rats ; Rats, Wistar ; Reperfusion ; Reperfusion Injury - etiology ; Reperfusion Injury - pathology ; Reperfusion Injury - prevention & control ; Stroke ; Tumor necrosis factor- alpha</subject><ispartof>Molecular and cellular biochemistry, 2012-08, Vol.367 (1-2), p.73-84</ispartof><rights>Springer Science+Business Media, LLC. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-16a8e3e69749e8bc96ce7441918a12479fee3027ffd45a0cc28ed545c1859a643</citedby><cites>FETCH-LOGICAL-c377t-16a8e3e69749e8bc96ce7441918a12479fee3027ffd45a0cc28ed545c1859a643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22669728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaibhav, Kumar</creatorcontrib><creatorcontrib>Shrivastava, Pallavi</creatorcontrib><creatorcontrib>Javed, Hayate</creatorcontrib><creatorcontrib>Khan, Andleeb</creatorcontrib><creatorcontrib>Ahmed, Md. Ejaz</creatorcontrib><creatorcontrib>Tabassum, Rizwana</creatorcontrib><creatorcontrib>Khan, Mohd. Moshahid</creatorcontrib><creatorcontrib>Khuwaja, Gulrana</creatorcontrib><creatorcontrib>Islam, Farah</creatorcontrib><creatorcontrib>Saeed Siddiqui, M.</creatorcontrib><creatorcontrib>Safhi, Mohammed M.</creatorcontrib><creatorcontrib>Islam, Fakhrul</creatorcontrib><title>Piperine suppresses cerebral ischemia–reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description><![CDATA[The pathophysiological mechanisms leading to neuronal injury in middle cerebral artery occlusion (MCAO) model of cerebral stroke are complex and multifactorial that form the bases of behavioral deficits and inflammation mediated damage. The present study demonstrates the effect of piperine pretreatment (10 mg/kg b wt, once daily p.o
.
for 15 days) on cerebral ischemia-induced inflammation in male Wistar rats. The right middle cerebral artery was occluded for 2 h followed by reperfusion for 22 h. A maximum infarct volume (57.80 %) was observed in ischemic MCAO group. However, piperine administration prior to ischemia showed a significant reduction in infarct volume (28.29 %;
p
< 0.05) and neuronal loss (12.72 %;
p
< 0.01). As a result of piperine pretreatment, a significant improvement in behavioral outputs of MCAO rats (
p
< 0.05–0.01) was observed. Piperine successfully reduced the level of proinflammatory cytokines IL-1β, IL-6 and TNF-α, in ischemic group (
p
< 0.01). Ischemic group brain has shown edematous morphology with vacuolated architecture and pyknotic nuclei in H & E staining which was successfully ameliorated by piperine administration. Moreover, piperine also succeeded in lowering the expression of COX-2, NOS-2, and NF-κB (
p
< 0.01). Both cytosolic and nuclear NF-κB were down-regulated in ischemic group pre-administered with piperine (
p
< 0.01). The present study suggests that piperine is able to salvage the ischemic penumbral zone neurons by virtue of its anti-inflammatory property, thereby limiting ischemic cell death.]]></description><subject>Alkaloids - pharmacology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antiinflammatory agents</subject><subject>Benzodioxoles - pharmacology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Brain</subject><subject>Cardiology</subject><subject>Cell death</subject><subject>Cerebral blood flow</subject><subject>Cyclooxygenase 2 - genetics</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Cyclooxygenase-2</subject><subject>Cytokines - blood</subject><subject>Cytokines - secretion</subject><subject>Down-Regulation - drug effects</subject><subject>Infarction, Middle Cerebral Artery - complications</subject><subject>Infarction, Middle Cerebral Artery - drug therapy</subject><subject>Infarction, Middle Cerebral Artery - pathology</subject><subject>Inflammation</subject><subject>Inflammation Mediators - blood</subject><subject>Injuries</subject><subject>Interleukin 1</subject><subject>Interleukin 6</subject><subject>Ischemia</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical Biochemistry</subject><subject>Motor Activity - drug effects</subject><subject>Muscle Strength - drug effects</subject><subject>Neurons</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>NF- Kappa B protein</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - metabolism</subject><subject>Nitric Oxide Synthase Type II - genetics</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Oncology</subject><subject>Piperidines - pharmacology</subject><subject>Polyunsaturated Alkamides - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reperfusion</subject><subject>Reperfusion Injury - etiology</subject><subject>Reperfusion Injury - pathology</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Stroke</subject><subject>Tumor necrosis factor- alpha</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kUFu1DAUhi1ERYfCAdggL1lg8HOcOFnCqKVIVQcJkNhZHvul4yqJg50s2hV34BRcoYfoIXoSHKaFHatfev7-_-n5J-QF8DfAuXqbADhwxkEwKASw60dkBaUqmGygeUxWvOCc1aDUIXma0iXPMAd4Qg6FqKpGiXpFfn3yI0Y_IE3zOEZMCRO1GHEbTUd9sjvsvbn78TNi5to5-TAwP7jZoqN-aDvT92bKQzrtYpgvdlmRZniJWsahpevNNyZe0_PN50XM4Oj5Cbu9eZ_9tPfOdfhvo4kTxisarO3-7KLRTLQPDrtn5KA1XcLn93pEvp4cf1mfsrPNh4_rd2fMFkpNDCpTY4H5PNlgvbVNZVFJCQ3UBoRUTYtYcKHa1snScGtFja6UpYW6bEwliyPyap87xvB9xjTpPn8Ddp0ZMMxJAxeyqpQqIaOwR20MKUVs9Rh9b-JVhvTSkN43pHNDemlIX2fPy_v4eduj--t4qCQDYg-k_DRcYNSXYY5DPvk_qb8BgzWgBA</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Vaibhav, Kumar</creator><creator>Shrivastava, Pallavi</creator><creator>Javed, Hayate</creator><creator>Khan, Andleeb</creator><creator>Ahmed, Md. Ejaz</creator><creator>Tabassum, Rizwana</creator><creator>Khan, Mohd. Moshahid</creator><creator>Khuwaja, Gulrana</creator><creator>Islam, Farah</creator><creator>Saeed Siddiqui, M.</creator><creator>Safhi, Mohammed M.</creator><creator>Islam, Fakhrul</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20120801</creationdate><title>Piperine suppresses cerebral ischemia–reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model</title><author>Vaibhav, Kumar ; Shrivastava, Pallavi ; Javed, Hayate ; Khan, Andleeb ; Ahmed, Md. Ejaz ; Tabassum, Rizwana ; Khan, Mohd. Moshahid ; Khuwaja, Gulrana ; Islam, Farah ; Saeed Siddiqui, M. ; Safhi, Mohammed M. ; Islam, Fakhrul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-16a8e3e69749e8bc96ce7441918a12479fee3027ffd45a0cc28ed545c1859a643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alkaloids - pharmacology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antiinflammatory agents</topic><topic>Benzodioxoles - pharmacology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Brain</topic><topic>Cardiology</topic><topic>Cell death</topic><topic>Cerebral blood flow</topic><topic>Cyclooxygenase 2 - genetics</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Cyclooxygenase-2</topic><topic>Cytokines - blood</topic><topic>Cytokines - secretion</topic><topic>Down-Regulation - drug effects</topic><topic>Infarction, Middle Cerebral Artery - complications</topic><topic>Infarction, Middle Cerebral Artery - drug therapy</topic><topic>Infarction, Middle Cerebral Artery - pathology</topic><topic>Inflammation</topic><topic>Inflammation Mediators - blood</topic><topic>Injuries</topic><topic>Interleukin 1</topic><topic>Interleukin 6</topic><topic>Ischemia</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical Biochemistry</topic><topic>Motor Activity - drug effects</topic><topic>Muscle Strength - drug effects</topic><topic>Neurons</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>NF- Kappa B protein</topic><topic>NF-kappa B - genetics</topic><topic>NF-kappa B - metabolism</topic><topic>Nitric Oxide Synthase Type II - genetics</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>Oncology</topic><topic>Piperidines - pharmacology</topic><topic>Polyunsaturated Alkamides - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reperfusion</topic><topic>Reperfusion Injury - etiology</topic><topic>Reperfusion Injury - pathology</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Stroke</topic><topic>Tumor necrosis factor- alpha</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaibhav, Kumar</creatorcontrib><creatorcontrib>Shrivastava, Pallavi</creatorcontrib><creatorcontrib>Javed, Hayate</creatorcontrib><creatorcontrib>Khan, Andleeb</creatorcontrib><creatorcontrib>Ahmed, Md. Ejaz</creatorcontrib><creatorcontrib>Tabassum, Rizwana</creatorcontrib><creatorcontrib>Khan, Mohd. Moshahid</creatorcontrib><creatorcontrib>Khuwaja, Gulrana</creatorcontrib><creatorcontrib>Islam, Farah</creatorcontrib><creatorcontrib>Saeed Siddiqui, M.</creatorcontrib><creatorcontrib>Safhi, Mohammed M.</creatorcontrib><creatorcontrib>Islam, Fakhrul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaibhav, Kumar</au><au>Shrivastava, Pallavi</au><au>Javed, Hayate</au><au>Khan, Andleeb</au><au>Ahmed, Md. Ejaz</au><au>Tabassum, Rizwana</au><au>Khan, Mohd. Moshahid</au><au>Khuwaja, Gulrana</au><au>Islam, Farah</au><au>Saeed Siddiqui, M.</au><au>Safhi, Mohammed M.</au><au>Islam, Fakhrul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Piperine suppresses cerebral ischemia–reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>367</volume><issue>1-2</issue><spage>73</spage><epage>84</epage><pages>73-84</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract><![CDATA[The pathophysiological mechanisms leading to neuronal injury in middle cerebral artery occlusion (MCAO) model of cerebral stroke are complex and multifactorial that form the bases of behavioral deficits and inflammation mediated damage. The present study demonstrates the effect of piperine pretreatment (10 mg/kg b wt, once daily p.o
.
for 15 days) on cerebral ischemia-induced inflammation in male Wistar rats. The right middle cerebral artery was occluded for 2 h followed by reperfusion for 22 h. A maximum infarct volume (57.80 %) was observed in ischemic MCAO group. However, piperine administration prior to ischemia showed a significant reduction in infarct volume (28.29 %;
p
< 0.05) and neuronal loss (12.72 %;
p
< 0.01). As a result of piperine pretreatment, a significant improvement in behavioral outputs of MCAO rats (
p
< 0.05–0.01) was observed. Piperine successfully reduced the level of proinflammatory cytokines IL-1β, IL-6 and TNF-α, in ischemic group (
p
< 0.01). Ischemic group brain has shown edematous morphology with vacuolated architecture and pyknotic nuclei in H & E staining which was successfully ameliorated by piperine administration. Moreover, piperine also succeeded in lowering the expression of COX-2, NOS-2, and NF-κB (
p
< 0.01). Both cytosolic and nuclear NF-κB were down-regulated in ischemic group pre-administered with piperine (
p
< 0.01). The present study suggests that piperine is able to salvage the ischemic penumbral zone neurons by virtue of its anti-inflammatory property, thereby limiting ischemic cell death.]]></abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22669728</pmid><doi>10.1007/s11010-012-1321-z</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Molecular and cellular biochemistry, 2012-08, Vol.367 (1-2), p.73-84 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1024667751 |
| source | Springer Nature |
| subjects | Alkaloids - pharmacology Animals Anti-Inflammatory Agents - pharmacology Antiinflammatory agents Benzodioxoles - pharmacology Biochemistry Biomedical and Life Sciences Brain Cardiology Cell death Cerebral blood flow Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines - blood Cytokines - secretion Down-Regulation - drug effects Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - pathology Inflammation Inflammation Mediators - blood Injuries Interleukin 1 Interleukin 6 Ischemia Life Sciences Male Medical Biochemistry Motor Activity - drug effects Muscle Strength - drug effects Neurons Neuroprotective Agents - pharmacology NF- Kappa B protein NF-kappa B - genetics NF-kappa B - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Oncology Piperidines - pharmacology Polyunsaturated Alkamides - pharmacology Rats Rats, Wistar Reperfusion Reperfusion Injury - etiology Reperfusion Injury - pathology Reperfusion Injury - prevention & control Stroke Tumor necrosis factor- alpha |
| title | Piperine suppresses cerebral ischemia–reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model |
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