Aleurites moluccana and its main active ingredient, the flavonoid 2 double prime -O-rhamnosylswertisin, have promising antinociceptive effects in experimental models of hypersensitivity in mice

This study investigated the antinociceptive effect of Aleurites moluccana dried extract (DE; 125 to 500mg/kg, p.o.) and the isolated flavonoid 2 double prime -O-rhamnosylswertisin (5 to 50.6 mu mol/kg, p.o.) using different models of long-lasting inflammatory and neuropathic pain in mice. Attempts w...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2012-08, Vol.102 (2), p.302-311
Main Authors: Quintao, Nara LM, Antonialli, Carla S, da Silva, Gislaine F, Rocha, Lilian W, de Souza, Marcia M, Malheiros, Angela, Meyre-Silva, Christiane, Lucinda-Silva, Ruth M, Bresolin, Tania MB, Filho, Valdir Cechinel
Format: Article
Language:English
Subjects:
Aleurites moluccana
Animal models
carrageenans
Dopamine
Flavonoids
Freund's adjuvant
gabapentin
Hypersensitivity
Inflammation
Interleukin 1
Leukocyte migration
Leukocytes (neutrophilic)
Locomotor activity
Medicinal plants
Motor task performance
Neuropathy
Opioids
Pain perception
Sciatic nerve
Side effects
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Summary:This study investigated the antinociceptive effect of Aleurites moluccana dried extract (DE; 125 to 500mg/kg, p.o.) and the isolated flavonoid 2 double prime -O-rhamnosylswertisin (5 to 50.6 mu mol/kg, p.o.) using different models of long-lasting inflammatory and neuropathic pain in mice. Attempts were made to analyse the mechanisms through which A. moluccana exerted its effects. A. moluccana DE inhibited complete Freund's adjuvant (CFA)-induced mechanical nociception. It was also evidenced by a reduction of sensitization in the contralateral hindpaw. The extract reversed the mechanical hypersensitivity of partial ligation of sciatic nerve (PLSN)-treated animals, similar to gabapentin. In PLSN model, the opioid, dopaminergic and oxidonitrergic pathways were involved in the A. moluccana DE antinociceptive effects. A single dose of 2 double prime -O-rhamnosylswertisin inhibited the carrageenan- and CFA-induced mechanical nociception. Furthermore, the compound caused expressive antinociception in PLSN-mice, with inhibition value greater than obtained with gabapentin. Oral treatment with the extract or the isolated compound attenuated the neutrophil migration and IL-1 beta levels following carrageenan injection. Of note, A. moluccana DE did not interfere with thermal sensitivity in healthy mice. The absence of side effects, including interference in locomotor activity, motor performance in animals treated with the extract, showed excellent potential for the therapeutic use of this medicinal plant in treating persistent pain in humans.
ISSN:0091-3057
DOI:10.1016/j.pbb.2012.05.005