Acute Spinal Cord Injury Induces Genetic Damage in Multiple Organs of Rats

Spinal cord injury (SCI) is a devastating condition with important functional and psychological consequences. However, the underlying mechanisms by which these alterations occur are still not fully understood. The aim of this study was to analyze genomic instability in multiple organs in the acute p...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2012-08, Vol.32 (6), p.949-952
Main Authors: Medalha, Carla C., Polesel, Fernanda S., da Silva, Victor Hugo Pereira, Martins, Renato Almeida, Pozzi, Renan, Ribeiro, Daniel A.
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
DNA Damage - genetics
Genomic Instability - genetics
Male
Neurobiology
Neurosciences
Organ Specificity - genetics
Rats
Rats, Wistar
Short Communication
Spinal Cord Injuries - genetics
Spinal Cord Injuries - pathology
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Summary:Spinal cord injury (SCI) is a devastating condition with important functional and psychological consequences. However, the underlying mechanisms by which these alterations occur are still not fully understood. The aim of this study was to analyze genomic instability in multiple organs in the acute phase of SCI by means of single cell gel (comet) assay. Rats were randomly distributed into two groups ( n  = 5): a SHAM and a SCI group killed 24 h after cord transection surgery. The results pointed out genetic damage in blood cells as depicted by the tail moment results. DNA breakage was also detected in liver and kidney cells after SCI. Taken together, our results suggest that SCI induces genomic damage in multiple organs of Wistar rats.
ISSN:0272-4340
1573-6830
1573-6830
DOI:10.1007/s10571-012-9825-3