Use of erlotinib throughout pregnancy: A case-report of a patient with metastatic lung adenocarcinoma

• Published in: Lung cancer (Amsterdam, Netherlands) Netherlands), 2012-08, Vol.77 (2), p.469-472
• Main Authors: Rivas, Giovanna, Llinás, Nestor, Bonilla, Carlos, Rubiano, Juan, Cuello, Javier, Arango, Natalia
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - drug therapy; Adenocarcinoma - genetics; Adult; Antineoplastic Agents - therapeutic use; Base Sequence; Biological and medical sciences; EGFR tyrosine kinase inhibitor; Erlotinib; Erlotinib Hydrochloride; Female; Hematology, Oncology and Palliative Medicine; Humans; Lung adenocarcinoma; Lung cancer; Lung Neoplasms - diagnosis; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Medical sciences; Metastasis; Mutation; Neoplasm Metastasis; Non-small cell lung carcinoma; Pneumology; Pregnancy; Pregnancy Complications, Neoplastic - diagnosis; Pregnancy Complications, Neoplastic - drug therapy; Pregnancy Outcome; Protein Kinase Inhibitors - therapeutic use; Pulmonary/Respiratory; Quinazolines - therapeutic use; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - genetics; Treatment; Treatment Outcome; Tumors; Tumors of the respiratory system and mediastinum
• ISSN: 0169-5002; 1872-8332
• DOI: 10.1016/j.lungcan.2012.03.026

Abstract The use of erlotinib throughout pregnancy has not been previously reported. We present the case of a 40 year-old female patient with stage IV lung adenocarcinoma, mediastinal, bone and cerebral metastasis, a EGFR mutation and no smoking history, who had begun first line treatment with erlotinib 150 mg once daily. After two and a half months of treatment a fourteen-week pregnancy was documented, and after informing on fetal risks secondary to erlotinib use and maternal risks secondary to treatment withholding, she decided to continue with treatment under clinical surveillance by both the oncology and obstetrics clinics. At thirty-three weeks gestation a live born 1600 g female was born by caesarean section without evidence of congenital malformations. Imaging assessment after eight months of treatment showed complete bone and central nervous system response and partial lung and mediastinal response. The patient is currently undergoing the 11th month of treatment and is asymptomatic, the baby is 4 months old and is in good health.