Correlations between Stroop task performance and white matter lesion measures in late-onset major depression

• Published in: Psychiatry research. Neuroimaging 2012-05, Vol.202 (2), p.142-149
• Main Authors: Dalby, Rikke B, Frandsen, Jesper, Chakravarty, M. Mallar, Ahdidan, Jamila, Sørensen, Leif, Rosenberg, Raben, Østergaard, Leif, Videbech, Poul
• Format: Article
• Language: English
• Subjects: Adult and adolescent clinical studies; Aged; Biological and medical sciences; Brain - pathology; Brain Mapping; Case-Control Studies; Cognition Disorders - etiology; Cognition Disorders - pathology; Depression; Depressive Disorder, Major - complications; Depressive Disorder, Major - pathology; Diffusion Tensor Imaging; Female; Geriatrics; Humans; Image Processing, Computer-Assisted; Late-onset depression; Major depression; Male; Medical sciences; Middle Aged; Mood disorders; Nerve Fibers, Myelinated - pathology; Neuropsychological Tests; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychomotor retardation; Psychopathology. Psychiatry; Radiology; Statistics as Topic; Stroop test; Tractography; White matter lesions
• ISSN: 0925-4927; 1872-7506
• DOI: 10.1016/j.pscychresns.2011.12.009

Abstract Cerebral white matter lesions (WMLs) are believed to play an important role in a subset of patients with late-onset depression by affecting the white matter connectivity in circuitries essential for mood and cognition. In this study we used diffusion tensor imaging-based (DTI-based) tractography to assess white matter fiber tracts affected by deep WMLs (DWMLs) in patients with late-onset major depression and age- and gender-matched controls. Tractography outcome, illustrated as pathways affected by DWMLs, was analyzed for associations with cognitive performance on the Stroop Test (ST). The patients ( n = 17) performed significantly worse on the ST than the controls ( n = 22). Poor performance on the ST correlated with higher lesion load. Regression analysis showed a significant correlation between poor performance on the ST and tracts affected by DWMLs in multiple brain areas in the control group, but very sparse correlation in the patient group. Our results suggest that DWMLs play an important role in the cognitive performance of controls,whereas their influence in depressed patients is overruled by additional, state-dependent factors. Future focus on the tract-specific localization of WMLs using DTI tractography may reveal important associations between neuroconnectivity and clinical measures.