Pregnancy-associated breast cancers: Do they differ from other breast cancers in young women?

Abstract The impact of pregnancy in the physiopathology of pregnancy-associated breast cancer (PABC) is still unclear. We compared the characteristics of PABCs and breast cancers not associated with pregnancy (non-PABCs) in terms of their loco-regional invasion and histological phenotype. We conduct...

Full description

Saved in:
Bibliographic Details
Published in:Breast (Edinburgh) 2012-08, Vol.21 (4), p.550-555
Main Authors: Genin, Anne-Sophie, Lesieur, Bénédicte, Gligorov, Joseph, Antoine, Martine, Selleret, Lise, Rouzier, Roman
Format: Article
Language:English
Subjects:
Adult
Age Factors
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cohort Studies
Female
Hematology, Oncology and Palliative Medicine
Humans
Immuno-phenotype
Lymphatic Metastasis
Neoplasm Invasiveness
Neoplasm Staging
Post-partum
Pregnancy
Pregnancy Complications, Neoplastic - metabolism
Pregnancy Complications, Neoplastic - pathology
Puerperal Disorders - metabolism
Puerperal Disorders - pathology
Receptor, ErbB-2 - metabolism
Retrospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The impact of pregnancy in the physiopathology of pregnancy-associated breast cancer (PABC) is still unclear. We compared the characteristics of PABCs and breast cancers not associated with pregnancy (non-PABCs) in terms of their loco-regional invasion and histological phenotype. We conducted a retrospective chart review on women less than 43 years of age treated for breast cancer from January 1, 2004 to December 31, 2010. We compared age at diagnosis, loco-regional invasion and histological data. We recorded 282 breast cancers in 276 patients. Forty-one tumors (14.5%) were PABCs. PABC patients were significantly younger than non-PABC patients. Compared with the non-PABCs, PABCs were twice more frequent advanced tumors (T3-4) and have twice more frequent HER2 over-expression and hormone negative status. The more aggressive histological profile observed in the PABCs, especially in post-partum tumors and women older than 35 years of age, seems to be a direct consequence of the association with pregnancy.
ISSN:0960-9776
1532-3080
DOI:10.1016/j.breast.2012.05.002