Low number of invariant NKT cells is associated with poor survival in acute myeloid leukemia

Background T lymphocytes play an important role in the immunosurveillance of patients with hematologic malignancies. No study has so far examined the association between the number of lymphocyte subsets at diagnosis and overall survival (OS). We examined this relationship in adult patients with de n...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2012-08, Vol.138 (8), p.1427-1432
Main Authors: Najera Chuc, Alicia E., Cervantes, Laura A. Montiel, Retiguin, Flor Pérez, Ojeda, Jorge Vela, Maldonado, Elba Reyes
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Aged
Antineoplastic agents
Biological and medical sciences
Bone Marrow Cells - pathology
Cancer Research
CD4-Positive T-Lymphocytes - pathology
CD8-Positive T-Lymphocytes - pathology
Female
Flow Cytometry
Hematologic and hematopoietic diseases
Hematology
Humans
Internal Medicine
Kaplan-Meier Estimate
Leukemia
Leukemia, Myeloid - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphocyte Count - statistics & numerical data
Lymphocytes
Male
Medical prognosis
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Natural Killer T-Cells - pathology
Oncology
Pharmacology. Drug treatments
Prognosis
Proportional Hazards Models
Prospective Studies
Rapid Communication
Young Adult
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Summary:Background T lymphocytes play an important role in the immunosurveillance of patients with hematologic malignancies. No study has so far examined the association between the number of lymphocyte subsets at diagnosis and overall survival (OS). We examined this relationship in adult patients with de novo acute myeloid leukemia (AML). Methods A longitudinal prospective study was conducted on 28 AML patients. Peripheral blood (PB) and bone marrow (BM) were obtained before chemotherapy to quantify the number of CD4+ and CD8+ T cells, natural killer (NK), invariant NKT (iNKT), and type-1 and type-2 dendritic cells. The Kaplan–Meier and Cox proportional hazard model were used to determine significant association between the number of each cell subtype and survival. Results BM counts of CD4+ lymphocytes >506.11/μL and CD8+ T lymphocytes >556.02/μL and a PB count of iNKT cells 
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-012-1251-x