Mechanisms of Action of Ladasten: Activation of Gene Expression for Neurotrophins and Mitogen-Activated Kinases

We studied the effects of single treatment with ladasten (50 mg/kg) on the content of effector kinases of the mitogen-activated cascade (ERK1/ERK2), pERK1/ERK2 activity (Thr202/Tyr204), and expression of genes for neurotrophic factors BDND and NGF in the striatum, hypothalamus, and hippocampus of ra...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012, Vol.152 (3), p.313-317
Main Authors: Salimgareeva, M. Kh, Yamidanov, R. S., Vakhitova, Yu. V., Seredenin, S. B.
Format: Article
Language:English
Subjects:
Adamantane - administration & dosage
Adamantane - analogs & derivatives
Adamantane - pharmacology
Animals
Biomedical and Life Sciences
Biomedicine
Brain-Derived Neurotrophic Factor - metabolism
Cell Biology
Corpus Striatum - metabolism
Densitometry
Extracellular Signal-Regulated MAP Kinases - metabolism
Gene expression
Gene Expression Regulation - drug effects
Gene Expression Regulation - physiology
Genes
Hippocampus - metabolism
Hypothalamus - metabolism
Immunoblotting
Internal Medicine
Laboratory Medicine
Male
Mitogens
Nerve growth factor
Nerve Growth Factors - metabolism
Pathology
Pharmacology and Toxicology
Phosphotransferases
Rats
Signal Transduction - drug effects
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Summary:We studied the effects of single treatment with ladasten (50 mg/kg) on the content of effector kinases of the mitogen-activated cascade (ERK1/ERK2), pERK1/ERK2 activity (Thr202/Tyr204), and expression of genes for neurotrophic factors BDND and NGF in the striatum, hypothalamus, and hippocampus of rats.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1516-z