Role of Variations in Pulmonary and Cardiac Hemodynamics in the Reduction of the Venous Return during Experimental Ischemia of the Left Ventricular Myocardium

• Published in: Bulletin of experimental biology and medicine 2012-02, Vol.152 (4), p.416-419
• Main Authors: Evlakhov, V. I., Poyassov, I. Z.
• Format: Article
• Language: English
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Blood Pressure - drug effects; Cats; Cell Biology; Electric Stimulation; Heart - drug effects; Heart - physiopathology; Heart beat; Heart Rate - drug effects; Heart Ventricles - physiopathology; Internal Medicine; Ischemia; Laboratory Medicine; Lung - blood supply; Lung - drug effects; Lung - physiopathology; Myocardial Contraction - drug effects; Myocardial Ischemia - physiopathology; Pathology; Propranolol - administration & dosage; Propranolol hydrochloride; Pulmonary Artery - drug effects; Pulmonary Artery - physiopathology; Rabbits; Stroke Volume - drug effects; Vagus Nerve - drug effects; Vagus Nerve - physiopathology; Vasodilator Agents - administration & dosage; Ventricular Dysfunction, Left - physiopathology
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-012-1542-x

During left-ventricular myocardial ischemia, the decrease in the venous return is determined by reduction of cardiac output, which results from heart rate deceleration and decrease in left-ventricular stroke volume. The latter is related to a decrease in myocardial contractility and blood storage in the pulmonary circuit. Blood accumulation in the lungs is not observed during stimulation of the vagus nerve or treatment with propranolol (against the background of the same values of the negative chronotropic and inotropic effects as during myocardial ischemia). The left-ventricular stroke volume increases, while the cardiac output and venous return decrease to a lesser extent under these conditions.