Role of Variations in Pulmonary and Cardiac Hemodynamics in the Reduction of the Venous Return during Experimental Ischemia of the Left Ventricular Myocardium

During left-ventricular myocardial ischemia, the decrease in the venous return is determined by reduction of cardiac output, which results from heart rate deceleration and decrease in left-ventricular stroke volume. The latter is related to a decrease in myocardial contractility and blood storage in...

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Published in:Bulletin of experimental biology and medicine 2012-02, Vol.152 (4), p.416-419
Main Authors: Evlakhov, V. I., Poyassov, I. Z.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Blood Pressure - drug effects
Cats
Cell Biology
Electric Stimulation
Heart - drug effects
Heart - physiopathology
Heart beat
Heart Rate - drug effects
Heart Ventricles - physiopathology
Internal Medicine
Ischemia
Laboratory Medicine
Lung - blood supply
Lung - drug effects
Lung - physiopathology
Myocardial Contraction - drug effects
Myocardial Ischemia - physiopathology
Pathology
Propranolol - administration & dosage
Propranolol hydrochloride
Pulmonary Artery - drug effects
Pulmonary Artery - physiopathology
Rabbits
Stroke Volume - drug effects
Vagus Nerve - drug effects
Vagus Nerve - physiopathology
Vasodilator Agents - administration & dosage
Ventricular Dysfunction, Left - physiopathology
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Poyassov, I. Z.
description During left-ventricular myocardial ischemia, the decrease in the venous return is determined by reduction of cardiac output, which results from heart rate deceleration and decrease in left-ventricular stroke volume. The latter is related to a decrease in myocardial contractility and blood storage in the pulmonary circuit. Blood accumulation in the lungs is not observed during stimulation of the vagus nerve or treatment with propranolol (against the background of the same values of the negative chronotropic and inotropic effects as during myocardial ischemia). The left-ventricular stroke volume increases, while the cardiac output and venous return decrease to a lesser extent under these conditions.
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ispartof Bulletin of experimental biology and medicine, 2012-02, Vol.152 (4), p.416-419
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1573-8221
language eng
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source Springer Nature
subjects Animals
Biomedical and Life Sciences
Biomedicine
Blood Pressure - drug effects
Cats
Cell Biology
Electric Stimulation
Heart - drug effects
Heart - physiopathology
Heart beat
Heart Rate - drug effects
Heart Ventricles - physiopathology
Internal Medicine
Ischemia
Laboratory Medicine
Lung - blood supply
Lung - drug effects
Lung - physiopathology
Myocardial Contraction - drug effects
Myocardial Ischemia - physiopathology
Pathology
Propranolol - administration & dosage
Propranolol hydrochloride
Pulmonary Artery - drug effects
Pulmonary Artery - physiopathology
Rabbits
Stroke Volume - drug effects
Vagus Nerve - drug effects
Vagus Nerve - physiopathology
Vasodilator Agents - administration & dosage
Ventricular Dysfunction, Left - physiopathology
title Role of Variations in Pulmonary and Cardiac Hemodynamics in the Reduction of the Venous Return during Experimental Ischemia of the Left Ventricular Myocardium
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