Haplotypes across the human caveolin 1 gene upstream purine complex significantly alter gene expression: Implication in neurodegenerative disorders

We have previously reported a polymorphic purine complex at the 1.5kb upstream region of the human caveolin 1 (CAV1) gene that is conserved across several species in respect with sequence motifs and the location of the complex. The IRF and Ets transcription factors have common binding sites for this...

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Bibliographic Details
Published in:Gene 2012-08, Vol.505 (1), p.186-189
Main Authors: Heidari, A., Hosseinkhani, S., Talebi, S., Meshkani, R., Esmaeilzadeh-Gharedaghi, E., Banan, M., Darvish, H., Ohadi, M.
Format: Article
Language:English
Subjects:
5' Untranslated Regions - genetics
Alzheimer disease
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
binding sites
Caveolin 1
Caveolin 1 - biosynthesis
Caveolin 1 - genetics
Cell Line, Tumor
Expression
gene expression
Gene Expression Regulation - genetics
genes
Haplotypes
homozygosity
Homozygote
Humans
luciferase
Multiple Sclerosis - genetics
Multiple Sclerosis - metabolism
neurodegenerative diseases
Neurodegenerative disorder
neurons
Proto-Oncogene Proteins c-ets - genetics
Proto-Oncogene Proteins c-ets - metabolism
Purine complex
sclerosis
t-test
transcription factors
Upstream
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Summary:We have previously reported a polymorphic purine complex at the 1.5kb upstream region of the human caveolin 1 (CAV1) gene that is conserved across several species in respect with sequence motifs and the location of the complex. The IRF and Ets transcription factors have common binding sites for this region across those species. We have also shown skew in the homozygote haplotype compartment of this complex in two neurodegenerative disorders, sporadic late-onset Alzheimer's disease (AD), and multiple sclerosis (MS), versus disease-free controls (p
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2012.05.018