Meta-analysis: the impact of IL28B polymorphisms on rapid and sustained virological response in HCV-2 and -3 patients

Summary Background Recent studies suggested that IL28B polymorphisms may affect rapid and sustained virological response rates in HCV patients infected with genotype 2 or 3. Aim To assess the role of IL28B polymorphisms on the virological response in HCV‐2 and ‐3 patients. Methods We performed meta‐...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2012-08, Vol.36 (4), p.353-362
Main Authors: Schreiber, J., Moreno, C., Garcia, B. Garcia, Louvet, A., Trepo, E., Henrion, J., Thabut, D., Mathurin, P., Deltenre, P.
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Biological and medical sciences
Digestive system
Gastroenterology. Liver. Pancreas. Abdomen
Genotype
Hepacivirus - genetics
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - genetics
Humans
Interferons
Interleukins - genetics
Medical sciences
Pharmacology. Drug treatments
Polymorphism, Genetic
Predictive Value of Tests
Treatment Outcome
Viral Load
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Summary:Summary Background Recent studies suggested that IL28B polymorphisms may affect rapid and sustained virological response rates in HCV patients infected with genotype 2 or 3. Aim To assess the role of IL28B polymorphisms on the virological response in HCV‐2 and ‐3 patients. Methods We performed meta‐analysis of studies evaluating the impact of rs12979860 and rs8099917 polymorphisms on rapid and sustained virological response in HCV‐2 or ‐3 patients. Results Twenty‐three studies involving 3042 patients were included. The first meta‐analysis evaluated the impact of rs12979860 polymorphism and included 1963 patients. When compared with rs12979860 CT/TT patients, CC patients had a higher rapid virological response rate (mean difference: 12.9%, 95% CI: 6.5–19.4%, P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2012.05197.x