Iron-Dependent Synthesis of Hemolysins by Staphylococcus aureus

We studied the effect of Fe 2+ on hemolysin synthesis by Staphylococcus aureus . Hemolytic activity of staphylococci was shown to be iron-dependent. Addition of Fe 2+ to the nutrient medium induced the synthesis of α-hemolysin by staphylococci. Increasing the concentration of Fe 2+ was followed by a...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-05, Vol.153 (1), p.41-43
Main Authors: Leonov, V. V., Kosterina, V. V., Varnitsina, V. V., Timokhina, T. Kh, Kurlovich, N. A.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cells, Cultured
Cholera toxin
Development and progression
Hemoglobin
Hemolysin Proteins - metabolism
Hemolysins
Hemolysis - physiology
Hemolysis and hemolysins
Humans
Infection
Internal Medicine
Iron
Iron - metabolism
Laboratory Medicine
Nutrients
Pathology
Staphylococcus aureus
Staphylococcus aureus - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the effect of Fe 2+ on hemolysin synthesis by Staphylococcus aureus . Hemolytic activity of staphylococci was shown to be iron-dependent. Addition of Fe 2+ to the nutrient medium induced the synthesis of α-hemolysin by staphylococci. Increasing the concentration of Fe 2+ was followed by an increase in hemolytic activity of staphylococci. Inducible synthesis of α-hemolysin probably serves as an important pathogenetic factor in the development of staphylococcal infection in patients with excessive iron accumulation in the body.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1645-4