Iron-Dependent Synthesis of Hemolysins by Staphylococcus aureus

We studied the effect of Fe 2+ on hemolysin synthesis by Staphylococcus aureus . Hemolytic activity of staphylococci was shown to be iron-dependent. Addition of Fe 2+ to the nutrient medium induced the synthesis of α-hemolysin by staphylococci. Increasing the concentration of Fe 2+ was followed by a...

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Published in:Bulletin of experimental biology and medicine 2012-05, Vol.153 (1), p.41-43
Main Authors: Leonov, V. V., Kosterina, V. V., Varnitsina, V. V., Timokhina, T. Kh, Kurlovich, N. A.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cells, Cultured
Cholera toxin
Development and progression
Hemoglobin
Hemolysin Proteins - metabolism
Hemolysins
Hemolysis - physiology
Hemolysis and hemolysins
Humans
Infection
Internal Medicine
Iron
Iron - metabolism
Laboratory Medicine
Nutrients
Pathology
Staphylococcus aureus
Staphylococcus aureus - metabolism
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creator Leonov, V. V.
Kosterina, V. V.
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description We studied the effect of Fe 2+ on hemolysin synthesis by Staphylococcus aureus . Hemolytic activity of staphylococci was shown to be iron-dependent. Addition of Fe 2+ to the nutrient medium induced the synthesis of α-hemolysin by staphylococci. Increasing the concentration of Fe 2+ was followed by an increase in hemolytic activity of staphylococci. Inducible synthesis of α-hemolysin probably serves as an important pathogenetic factor in the development of staphylococcal infection in patients with excessive iron accumulation in the body.
doi_str_mv 10.1007/s10517-012-1645-4
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1573-8221
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source Springer Nature
subjects Biomedical and Life Sciences
Biomedicine
Cell Biology
Cells, Cultured
Cholera toxin
Development and progression
Hemoglobin
Hemolysin Proteins - metabolism
Hemolysins
Hemolysis - physiology
Hemolysis and hemolysins
Humans
Infection
Internal Medicine
Iron
Iron - metabolism
Laboratory Medicine
Nutrients
Pathology
Staphylococcus aureus
Staphylococcus aureus - metabolism
title Iron-Dependent Synthesis of Hemolysins by Staphylococcus aureus
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