Increased plasma 8,12-iso-iPF2alpha- VI levels in relapsing multiple sclerosis patients are not predictive of disease progression

Background: Oxidative stress plays an important role in multiple sclerosis (MS). Isoprostanes are biomarkers for oxidative stress and have been related to neurological disease progression. Objective: To study whether plasma isoprostane levels were related to disease progression in MS. Methods: Plasm...

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Bibliographic Details
Published in:Multiple sclerosis 2012-08, Vol.18 (8), p.1092-1098
Main Authors: Teunissen, CE, Sombekke, M, van Winsen, L, Killestein, J, Barkhof, F, Polman, CH, Dijkstra, CD, Blankenstein, MA, Pratico, D
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers - blood
Biomarkers - cerebrospinal fluid
Contrast Media
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Demyelinating Diseases - blood
Demyelinating Diseases - diagnosis
Dinoprost - analogs & derivatives
Dinoprost - blood
Dinoprost - cerebrospinal fluid
Disability Evaluation
Disease Progression
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Multiple Sclerosis, Chronic Progressive - blood
Multiple Sclerosis, Chronic Progressive - diagnosis
Multiple Sclerosis, Relapsing-Remitting - blood
Multiple Sclerosis, Relapsing-Remitting - cerebrospinal fluid
Multiple Sclerosis, Relapsing-Remitting - diagnosis
Multiple Sclerosis, Relapsing-Remitting - pathology
Netherlands
Neurology
Predictive Value of Tests
Prognosis
Time Factors
Up-Regulation
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Summary:Background: Oxidative stress plays an important role in multiple sclerosis (MS). Isoprostanes are biomarkers for oxidative stress and have been related to neurological disease progression. Objective: To study whether plasma isoprostane levels were related to disease progression in MS. Methods: Plasma levels of 8,12-iso-iPF2alpha-VI were determined in 17 patients with clinically isolated syndrome (CIS), 41 relapsing–remitting MS (RRMS) patients and 5 primary progressive MS (PPMS) patients and related to MRI and clinical disease parameters. Results: Isoprostane levels were similar in CIS (60.9, interquartile range (IQR): 47.7–77.7 pg/ml) and RRMS patients (65.3, IQR: 51.9–82.8 pg/ml). The plasma levels were lower in PPMS patients (42.5, IQR: 37.1–49.9) pg/ml, p
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458511433306