Sculpting Organs: Mechanical Regulation of Tissue Development

The ramified architectures of organs such as the mammary gland and lung are generated via branching morphogenesis, a developmental process through which individual cells bud and pinch off of pre-existing epithelial sheets. Although specified by signaling programs, organ development requires integrat...

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Bibliographic Details
Published in:Annual review of biomedical engineering 2012-08, Vol.14 (1), p.129-154
Main Authors: Nelson, Celeste M, Gleghorn, Jason P
Format: Article
Language:English
Subjects:
Animals
Biomedical Engineering - methods
branching morphogenesis
Gene Expression Regulation, Developmental
gradient
Humans
Lung - physiology
Mammary Glands, Animal - growth & development
Mammary Glands, Human - growth & development
mechanotransduction
Models, Genetic
morphogen
Morphogenesis - physiology
Organogenesis
patterning
Signal Transduction - physiology
tension
Time Factors
Tissue Engineering - methods
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Summary:The ramified architectures of organs such as the mammary gland and lung are generated via branching morphogenesis, a developmental process through which individual cells bud and pinch off of pre-existing epithelial sheets. Although specified by signaling programs, organ development requires integration of all aspects of the microenvironment. We describe the essential role of endogenous cellular contractility in the formation of branching tubes. We also highlight the role of exogenous forces in normal and aberrant branching.
ISSN:1523-9829
1545-4274
DOI:10.1146/annurev-bioeng-071811-150043