Prevalence of metabolic syndrome in patients with angiographically proven coronary artery disease presenting to a tertiary care hospital in Delhi, India

• Published in: Diabetes & metabolic syndrome clinical research & reviews 2011-04, Vol.5 (2), p.53-60
• Main Authors: Goswami, Binita, Tayal, Devika, Tyagi, Sanjay, Mallika, V
• Format: Article
• Language: English
• Subjects: Aged; Cohort Studies; Coronary Angiography - trends; Coronary artery disease; Coronary Artery Disease - diagnosis; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - epidemiology; Diagnosis, Differential; Endocrinology & Metabolism; Female; Humans; IDF; India - epidemiology; Male; Metabolic syndrome; Metabolic Syndrome - diagnosis; Metabolic Syndrome - diagnostic imaging; Metabolic Syndrome - epidemiology; Middle Aged; NCEP ATP III; Prevalence; Risk Factors; Tertiary Healthcare - trends; WHO
• ISSN: 1871-4021; 1878-0334
• DOI: 10.1016/j.dsx.2010.12.008

Abstract Background Coronary artery disease is fast emerging as the major concern for afflicting people across the globe. The Indian subcontinent is highly predisposed to this condition due to distinctive risk factor profile of this population. This fact has led to a condition where the current preventative and management protocols that have worked well in the non-Asian Indian Caucasian populations, have failed to bring about the anticipated control over the incidence and progression of CAD in Asian Indians. Metabolic syndrome has been identified as a major determinant of CAD in this population. Materials and methods The prevalence of metabolic syndrome was determined in 431 patients undergoing coronary angiography through various diagnostic algorithms. The Asian modified diagnostic criteria were also implemented to estimate the metabolic syndrome prevalence in patients with different levels of stenosis. Results We observed a high incidence of metabolic syndrome in the patients with coronary artery disease. The prevalence of MS increased with increase in severity of coronary artery involvement. The IDF guideline with Asian modification was the most successful diagnostic algorithm. Conclusions It is now imperative to acknowledge the unique pattern of CAD and risk factor profile prevalent among South Asians. This will facilitate more focused and individualized management protocols directed to this population. Metabolic syndrome is a major syndrome prevalent in this population. Hence, effective control of MS may help in reducing the morbidity and mortality due to CAD in a great way.