Critical Moments in Time: Reflections on the Development of Orthogonal Acceleration Time-of-Flight Mass Spectrometry

This paper reflects on the historical development of orthogonal acceleration time-of-flight analyzers that have been used routinely for high sensitivity analyses of biological molecules for more than a decade. In particular, the role of the late Michael Guilhaus from the University of New South Wale...

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Bibliographic Details
Published in:Journal of the American Society for Mass Spectrometry 2012-08, Vol.23 (8), p.1301-1305
Main Author: Sheil, Margaret M.
Format: Article
Language:English
Subjects:
Acceleration
Analytical Chemistry
Analyzers
Bioinformatics
Biotechnology
Chemistry
Chemistry and Materials Science
Commercialization
Critical Insight
Ions
Mass spectrometry
New technology
Organic Chemistry
Proteomics
Sensitivity analysis
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Summary:This paper reflects on the historical development of orthogonal acceleration time-of-flight analyzers that have been used routinely for high sensitivity analyses of biological molecules for more than a decade. In particular, the role of the late Michael Guilhaus from the University of New South Wales in Australia is highlighted. This account shows that like most advances in science, successful commercialization of new technology is not straightforward and is often the result of critical contributions of different people and organizations at different points in time.
ISSN:1044-0305
1879-1123
DOI:10.1007/s13361-012-0398-7