Visual Field and Ocular Safety During Short-Term Vigabatrin Treatment in Cocaine Abusers

Purpose To evaluate the ocular safety of short-term vigabatrin treatment of cocaine abuse. Design Multicenter, prospective, randomized, placebo-controlled, double-masked, parallel assignment study. Methods Cocaine addicts were randomized to receive vigabatrin 3000 mg/day, cumulative dose 218 g (n =...

Full description

Saved in:
Bibliographic Details
Published in:American journal of ophthalmology 2012-08, Vol.154 (2), p.326-332.e2
Main Authors: Berezina, Tamara L, Khouri, Albert S, Winship, M. Douglas, Fechtner, Robert D
Format: Article
Language:English
Subjects:
4-Aminobutyrate Transaminase - antagonists & inhibitors
Adult
Aged
Biological and medical sciences
Biomedical research
Clinical trials
Cocaine-Related Disorders - drug therapy
Cocaine-Related Disorders - physiopathology
Diabetic retinopathy
Double-Blind Method
Enzyme Inhibitors - adverse effects
Enzyme Inhibitors - therapeutic use
Eyes & eyesight
Female
Field study
GABA Agents - adverse effects
GABA Agents - therapeutic use
Glaucoma
Health Insurance Portability & Accountability Act 1996-US
Humans
Hypertension
Male
Medical sciences
Middle Aged
Miscellaneous
Ophthalmology
Prospective Studies
Retina - drug effects
Substance abuse treatment
Vigabatrin - adverse effects
Vigabatrin - therapeutic use
Visual Acuity - drug effects
Visual Fields - drug effects
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To evaluate the ocular safety of short-term vigabatrin treatment of cocaine abuse. Design Multicenter, prospective, randomized, placebo-controlled, double-masked, parallel assignment study. Methods Cocaine addicts were randomized to receive vigabatrin 3000 mg/day, cumulative dose 218 g (n = 92), or placebo (n = 94) for 12 weeks. Subjects underwent examination of visual acuity (ETDRS) and peripheral visual field (PVF) by Humphrey Field Analyzer (HFA) 60-4 program before and after treatment. Reliable PVF tests (fixation loss, false positive, and false negative
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2012.02.026