Integration of cell biology, pharmacological modeling and statistical analysis Part I: Cell biology and PK/PD in the Oncology paradigm

The motivation of this two-part review article is to provide a comprehensive picture of cancer, cancer drugs and the detection and treatment of cancer. In order to do so, this article integrates the cell biology and biophysics of cancer as well as the modeling of preclinical Oncology drug data and s...

Full description

Saved in:
Bibliographic Details
Published in:Critical reviews in oncology/hematology 2012-08, Vol.83 (2), p.153-169
Main Authors: ANANTHAKRISHNAN, Revathi, MENON, Sandeep
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Clinical Trials as Topic
Hematologic and hematopoietic diseases
Humans
Medical sciences
Models, Biological
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - metabolism
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The motivation of this two-part review article is to provide a comprehensive picture of cancer, cancer drugs and the detection and treatment of cancer. In order to do so, this article integrates the cell biology and biophysics of cancer as well as the modeling of preclinical Oncology drug data and statistical analysis of Oncology clinical trials data. It also discusses novel cancer diagnostic tools and standard and potential treatment options.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2011.10.004